Document Detail


Correction effect of ATP on platelet aggregation and blood coagulation in vitro and in the presence of circulating thrombin in rats.
MedLine Citation:
PMID:  18214281     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ATP added to plasma samples in concentrations of 5x10(-3)-5x10(-5) M in vitro decreased ADP-induced platelet aggregation. Platelet aggregation stimulated with thrombin under similar experimental in vitro conditions significantly decreased in the presence of 5x10(-6) M ATP and tended to decrease under the influence of ATP in concentrations of 5x10(-3) and 5x10(-7)-5x10(-9) M ATP. When endogenous thrombin in the circulation was stimulated by intravenous infusion of tissue thromboplastin, pretreatment with ATP (4 intramuscular injections, 0.75 mg/kg) produced a correction effect and normalized disturbed anticoagulant activity and platelet aggregation.
Authors:
V E Pastorova; L A Lyapina
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  143     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-91     Citation Subset:  IM    
Affiliation:
Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / pharmacology
Adenosine Triphosphate / pharmacology*
Animals
Blood Coagulation / drug effects*
Dose-Response Relationship, Drug
Platelet Aggregation / drug effects*
Rats
Thrombin / metabolism,  pharmacology*,  physiology
Thromboplastin / pharmacology
Chemical
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 9035-58-9/Thromboplastin; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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