| Correction of differential intensity inhomogeneity in longitudinal MR images. | |
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MedLine Citation:
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PMID: 15325354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Longitudinal MR imaging is increasingly being used to measure cerebral atrophy progression in dementia and other neurological disorders. Differences in intensity inhomogeneity between serial scans can confound these measurements. This differential bias also distorts nonlinear registration and makes both manual and automated segmentation of tissue type less reliable. A technique is described for the correction of this differential bias that makes no assumptions about signal distribution, bias field or signal homogeneity. Instead, the bias field calculation is performed on the basis that the remaining structure in the difference image of registered serial scans has small-scale structure. The differential bias field is of much larger scale and can thus be obtained by applying an appropriate filter to the difference image. The serial scan pair is then corrected for the differential bias field and atrophy measurement can be performed on the corrected scan pair. Application of a known, simulated bias field to real serial MR images was shown to alter atrophy measurements significantly. The differential correction method recovered the applied differential bias field and thereby improved atrophy measurements. This method was then applied to serial imaging in patients with dementia using a set of serial scan pairs with visually identified, significant differential bias and a set of scan pairs with negligible differential bias. Differential bias correction specifically reduced the variance of the atrophy measure significantly for the scans with significant differential bias. |
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Authors:
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Emma B Lewis; Nicholas C Fox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: NeuroImage Volume: 23 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2004-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 75-83 Citation Subset: IM |
Affiliation:
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Dementia Research Group, Institute of Neurology, University College London, London, WC1N 3BG, UK. elewis@dementia.ion.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Alzheimer Disease / diagnosis*, pathology Analysis of Variance Artifacts Atrophy Bias (Epidemiology) Brain / pathology* Cerebellum / pathology Cerebral Ventricles / pathology Computer Simulation Humans Image Enhancement* Image Processing, Computer-Assisted / statistics & numerical data* Magnetic Resonance Imaging / statistics & numerical data* Reference Values |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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