Document Detail


Correcting iron-restricted erythropoiesis and improving anemia in patients on hemodialysis: practical tips that can make a difference.
MedLine Citation:
PMID:  19856814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In healthy individuals, the body remains in an iron-balanced state. Iron intake and loss on a daily basis is minimal, and the majority of iron in the body is recycled. However, patients on hemodialysis may have an insufficient supply of iron available to the bone marrow for erythropoiesis, a condition known as iron-restricted erythropoiesis or inflammation-mediated reticuloendothelial blockade. This state may occur as a result of an inflammatory process and can limit the patient's ability to respond to erythropoiesis-stimulating agents (ESAs). Intravenous (IV) iron supplementation may be needed to overcome iron-restricted erythropoiesis and improve ESA response. This article focuses on the complex relationship among the three I's in anemia management: inflammation, iron-restricted erythropoiesis, and IV iron treatment.
Authors:
Andrea Easom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology nursing journal : journal of the American Nephrology Nurses' Association     Volume:  36     ISSN:  1526-744X     ISO Abbreviation:  Nephrol Nurs J     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-10-27     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909377     Medline TA:  Nephrol Nurs J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-37, 553     Citation Subset:  N    
Affiliation:
Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR. USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia / complications,  drug therapy*
Dose-Response Relationship, Drug
Erythropoiesis*
Hematinics / administration & dosage,  therapeutic use*
Humans
Inflammation / complications
Iron / blood*
Kidney Failure, Chronic / complications,  therapy*
Renal Dialysis*
Chemical
Reg. No./Substance:
0/Hematinics; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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