| Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment. | |
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MedLine Citation:
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PMID: 11747143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effects of streptozotocin-induced diabetes on nitric oxide (NO)-mediated relaxation of rat corpus cavernosum smooth muscle to neurogenic and endothelial stimulation was examined. The aim was to assess the effects of treatment with low doses of the antioxidant, alpha-lipoic acid, and the omega-6 essential fatty acid, gamma-linolenic acid, either separately or in combination. METHODS: Treatment was preventive from diabetes induction or corrective over 4 weeks after 4 weeks of untreated diabetes. Corpus cavernosum responses were examined in vitro. RESULTS: Neither diabetes nor treatment affected contractile responses to transmural electrical field stimulation of noradrenergic nerves. Stimulation of phenylephrine precontracted cavernosa in the presence of guanethidine and atropine caused relaxation via the nitrergic innervation. Maximum relaxation responses were 40% and 46% decreased after 4 and 8 weeks of diabetes, respectively. alpha-Lipoic acid, gamma-linolenic acid combination treatment fully prevented this deficit, and partially (52%) corrected the effect of 4 weeks of untreated diabetes. Neither alpha-lipoic acid nor gamma-linolenic components alone had significant effects, which suggests that there were synergistic interactions between the drugs. Both 4 and 8 weeks of untreated diabetes reduced maximum endothelium-dependent relaxation of phenylephrine precontracted cavernosa to acetylcholine by approximately 40%. While alpha-lipoic acid or gamma-linolenic acid were ineffective, joint treatment fully prevented and corrected this diabetic endothelial deficit. Neither diabetes nor treatment affected endothelium-independent relaxation to the NO donor, sodium nitroprusside. CONCLUSION: The data show that alpha-lipoic acid and gamma-linolenic acid interact synergistically to improve NO-mediated neurogenic and endothelium-dependent relaxation of corpus cavernosum in experimental diabetes. |
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Authors:
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A Keegan; M A Cotter; N E Cameron |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: 17 ISSN: 1520-7552 ISO Abbreviation: Diabetes Metab. Res. Rev. Publication Date: 2001 Sep-Oct |
Date Detail:
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Created Date: 2001-12-17 Completed Date: 2002-01-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: England |
Other Details:
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Languages: eng Pagination: 380-6 Citation Subset: IM |
Copyright Information:
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Copyright 2001 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Biomedical Sciences, University of Aberdeen, Aberdeen, Scotland, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Antioxidants / therapeutic use* Blood Glucose / analysis Diabetes Mellitus, Experimental / complications* Drug Therapy, Combination Electric Stimulation Erectile Dysfunction / drug therapy*, etiology* Male Muscle Contraction / drug effects Muscle Relaxation / drug effects Muscle, Smooth / blood supply, innervation, physiopathology Nitric Oxide / pharmacology Nitric Oxide Donors / pharmacology Nitroarginine / pharmacology Nitroprusside / pharmacology Penis / blood supply, innervation Phenylephrine / pharmacology Rats Rats, Sprague-Dawley Thioctic Acid / administration & dosage, therapeutic use* gamma-Linolenic Acid / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Blood Glucose; 0/Nitric Oxide Donors; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 2149-70-4/Nitroarginine; 506-26-3/gamma-Linolenic Acid; 51-84-3/Acetylcholine; 59-42-7/Phenylephrine; 62-46-4/Thioctic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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