Document Detail

Corpus callosum size and neuropsychologic impairment in adolescents who were born preterm.
MedLine Citation:
PMID:  16901446     Owner:  NLM     Status:  MEDLINE    
Prematurity is associated with cerebral abnormalities that might account for poorer cognitive performance. The aim of our study was to investigate the correlations between corpus callosum reductions and neuropsychologic performance in adolescents who were born preterm. Twenty-five subjects born before 33 weeks' gestation were compared with 25 subjects born at term and of similar age, gender, and sociocultural status. All subjects underwent magnetic resonance imaging and neuropsychologic examinations. Premature subjects performed worse than controls in global cognitive functioning, verbal memory, and verbal fluency. Corpus callosum measurements showed a global reduction owing mainly to thinning in the splenium, posterior midbody, and genu. Corpus callosum size significantly correlated with gestational age, Wechsler Performance IQ, and memory performance. These results suggest that cerebral growth during infancy does not compensate for corpus callosum reduction and that this reduction reflects neuropsychologic deficit. The cognitive impairment can arise from the paucity of the complex interneuronal connections owing to fiber damage, particularly myelinated fibers.
Xavier Caldú; Ana Narberhaus; Carme Junqué; Mónica Giménez; Pere Vendrell; Núria Bargalló; Dolors Segarra; Francesc Botet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of child neurology     Volume:  21     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-08-11     Completed Date:  2006-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  406-10     Citation Subset:  IM    
Department of Psychiaty and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
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MeSH Terms
Case-Control Studies
Cognition Disorders / pathology*,  psychology
Corpus Callosum / pathology*
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / pathology*,  psychology
Neuropsychological Tests
Organ Size

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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