Document Detail

Corpus callosum size and inter-hemispheric function in schizophrenia.
MedLine Citation:
PMID:  9075296     Owner:  NLM     Status:  MEDLINE    
We studied the relationship between corpus callosum area and both inter-hemispheric facilitation and interference in schizophrenics and controls. Mid-sagittal sections through the corpus callosum were measured using structural magnetic resonance imaging on 42 patients and 43 normal controls, along with symptom profiles. In a sub-sample, a modified version of the Stroop Test was also performed (27 patients and 29 controls) to assess inter-hemispheric facilitation and interference of colour naming. In the larger sample (total subjects, n = 85), there were no significant differences between patients and controls in CC area but a trend towards smaller values in patients in all but the posterior segment. In the sub-sample, bilateral facilitation was greater, and interference, less in schizophrenics compared with controls. There was a positive correlation between facilitation and posterior CC area, parallelled by a negative correlation between interference and posterior CC area, in both patients and controls, which only reached statistical significance when both groups were combined. These findings suggest that the link, between CC size and neuropsychological processes involving inter-hemispheric transfer of information, is common to both schizophrenics and normal controls. There were significant negative correlations between anterior CC area and psychomotor poverty (avolition, anhedonia and affective flattening), and a suggestion that the negative correlation between age and CC size in controls was not present in patients.
P W Woodruff; M L Phillips; T Rushe; I C Wright; R M Murray; A S David
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  23     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-07-09     Completed Date:  1997-07-09     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
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MeSH Terms
Affect / physiology
Age Factors
Attention / pathology*,  physiopathology
Case-Control Studies
Corpus Callosum / pathology*,  physiopathology
Delusions / physiopathology
Functional Laterality / physiology
Magnetic Resonance Imaging
Middle Aged
Neuropsychological Tests
Regression Analysis
Schizophrenia / pathology*,  physiopathology*
Schizophrenic Psychology*
Visual Fields / physiology
Volition / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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