Document Detail

Corpus callosum shape changes in early Alzheimer's disease: an MRI study using the OASIS brain database.
MedLine Citation:
PMID:  23322167     Owner:  NLM     Status:  Publisher    
The corpus callosum (CC) is the largest fiber bundle connecting the left and right cerebral hemispheres. It has been a region examined extensively for indications of various pathologies, including Alzheimer's disease (AD). Almost all previous studies of the CC in AD have been concerned with its size, particularly its mid-sagittal cross-sectional area (CCA). In this study, we show that the CC shape, characterized by its circularity (CIR), may be affected more profoundly than its size in early AD. MRI scans (n = 196) were obtained from the publicly available Open Access Series of Imaging Studies database. The CC cross-sectional region on the mid-sagittal section of the brain was automatically segmented using a novel algorithm. The CCA and CIR were compared in 98 normal controls (NC) subjects, 70 patients with very mild AD (AD-VM), and 28 patients with mild AD (AD-M). Statistical analysis of covariance controlling for age and intracranial capacity showed that both the CIR and the CCA were significantly reduced in the AD-VM group relative to the NC group (CIR: p = 0.004; CCA: p = 0.005). However, only the CIR was significantly different between the AD-M and AD-VM groups (p = 0.006) being smaller in the former. The CCA was not significantly different between the AD-M and AD-VM groups. The results suggest that CC shape may be a more sensitive marker than its size for monitoring the progression of AD. In order to facilitate independent analyses, the CC segmentations and the CCA and CIR data used in this study have been made publicly available ( ).
Babak A Ardekani; Alvin H Bachman; Khadija Figarsky; John J Sidtis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Brain structure & function     Volume:  -     ISSN:  1863-2661     ISO Abbreviation:  Brain Struct Funct     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282001     Medline TA:  Brain Struct Funct     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY, 10962, USA,
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