Document Detail


Corpus callosum shape changes in early Alzheimer's disease: an MRI study using the OASIS brain database.
MedLine Citation:
PMID:  23322167     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The corpus callosum (CC) is the largest fiber bundle connecting the left and right cerebral hemispheres. It has been a region examined extensively for indications of various pathologies, including Alzheimer's disease (AD). Almost all previous studies of the CC in AD have been concerned with its size, particularly its mid-sagittal cross-sectional area (CCA). In this study, we show that the CC shape, characterized by its circularity (CIR), may be affected more profoundly than its size in early AD. MRI scans (n = 196) were obtained from the publicly available Open Access Series of Imaging Studies database. The CC cross-sectional region on the mid-sagittal section of the brain was automatically segmented using a novel algorithm. The CCA and CIR were compared in 98 normal controls (NC) subjects, 70 patients with very mild AD (AD-VM), and 28 patients with mild AD (AD-M). Statistical analysis of covariance controlling for age and intracranial capacity showed that both the CIR and the CCA were significantly reduced in the AD-VM group relative to the NC group (CIR: p = 0.004; CCA: p = 0.005). However, only the CIR was significantly different between the AD-M and AD-VM groups (p = 0.006) being smaller in the former. The CCA was not significantly different between the AD-M and AD-VM groups. The results suggest that CC shape may be a more sensitive marker than its size for monitoring the progression of AD. In order to facilitate independent analyses, the CC segmentations and the CCA and CIR data used in this study have been made publicly available ( http://www.nitrc.org/projects/art ).
Authors:
Babak A Ardekani; Alvin H Bachman; Khadija Figarsky; John J Sidtis
Related Documents :
20683387 - The effect of a new anular repair after discectomy in intervertebral disc degeneration:...
22922857 - Role of magnetic resonance imaging in evaluation of tubercular spondylitis: pattern of ...
23072837 - Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical gl...
23116727 - Impact of 18f-fdg pet/ct on therapeutic decisions in patients with colorectal cancer an...
574207 - The "hypernormal" ct scan in dementia: bilateral isodense subdural hematomas.
20882367 - Impact of intraventricular hemorrhage upon intracerebral hematoma expansion.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Brain structure & function     Volume:  -     ISSN:  1863-2661     ISO Abbreviation:  Brain Struct Funct     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282001     Medline TA:  Brain Struct Funct     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY, 10962, USA, ardekani@nki.rfmh.org.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast prolifera...
Next Document:  Calcium-ion-induced stabilization of the protease from Bacillus cereus WQ9-2 in aqueous hydrophilic ...