| Corpus callosum morphology in children and adolescents with attention deficit hyperactivity disorder: a meta-analytic review. | |
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MedLine Citation:
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PMID: 18444712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have examined corpus callosum (CC) morphology in children and adolescents with attention deficit hyperactivity disorder (ADHD). A meta-analysis of atypical brain morphology in children and adolescents with ADHD by Valera, Faraone, Murray, and Seidman (2006) reported a reduction in the splenium of the CC in this group compared with healthy controls. This meta-analysis undertook a more detailed examination of callosal morphology by also considering comorbid conditions and gender differences. The data from 13 studies were analyzed. Consistent with Valera et al. (2006), the splenium was smaller in children and adolescents with ADHD than in healthy controls. However, this result appears to be the result of a smaller splenium in females with ADHD. In addition, boys exhibited a smaller rostral body. There were no significant differences in CC measurements of studies that included ADHD samples with comorbid conditions. However, comorbidities were not consistently reported, making it difficult to accurately evaluate the impact of comorbidity on CC size. Additional research is needed to investigate whether gender differences reflect different ADHD subtypes. In addition, it is not known if these CC differences persist into adulthood. |
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Authors:
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A D Hutchinson; J L Mathias; M T Banich |
Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuropsychology Volume: 22 ISSN: 0894-4105 ISO Abbreviation: Neuropsychology Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-30 Completed Date: 2008-07-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904467 Medline TA: Neuropsychology Country: United States |
Other Details:
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Languages: eng Pagination: 341-9 Citation Subset: IM |
Affiliation:
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School of Psychology, University of Adelaide, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Attention Deficit Disorder with Hyperactivity / pathology*, physiopathology Child Corpus Callosum / pathology* Female Humans Male Psychiatric Status Rating Scales Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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R01 070037//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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