Document Detail

Corpus Callosum Atrophy - A Simple Predictor of Multiple Sclerosis Progression: A Longitudinal 9-Year Study.
MedLine Citation:
PMID:  22677920     Owner:  NLM     Status:  Publisher    
Aim: To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. Methods: In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T(2) and T(1) lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years. Results: Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35). Conclusion: Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.
M Vaneckova; T Kalincik; J Krasensky; D Horakova; E Havrdova; T Hrebikova; Z Seidl
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-06
Journal Detail:
Title:  European neurology     Volume:  68     ISSN:  1421-9913     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  23-27     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
MR Unit, Department of Radiodiagnostics, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic.
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