Document Detail


Corozalic Acid: a key okadaic Acid biosynthetic precursor with phosphatase inhibition activity.
MedLine Citation:
PMID:  20803584     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Toxin precursors: Corozalic acid, a new Ser/Thr protein phosphatase 1 and 2A inhibitor that turned out to be a key metabolic intermediate, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. Detailed spectroscopic analysis and extensive computational calculations revealed its structure and conformational behavior. In addition, a comprehensive picture of the interactions of corozalic acid with PP1 and PP2A is proposed on the basis of ab initio, docking and molecular dynamics calculations.
Authors:
José G Napolitano; Manuel Norte; José Javier Fernández; Antonio Hernández Daranas
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Publication Detail:
Type:  Journal Article     Date:  2010-08-27
Journal Detail:
Title:  Chemistry (Weinheim an der Bergstrasse, Germany)     Volume:  16     ISSN:  1521-3765     ISO Abbreviation:  Chemistry     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513783     Medline TA:  Chemistry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  11576-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Instituto Universitario de Bio-Orgánica "Antonio González", Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife (Spain), Fax: (+34) 922-318571.
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