Document Detail


Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis.
MedLine Citation:
PMID:  10442448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute monosymptomatic optic neuritis (AMON) may be an initial symptom of multiple sclerosis (MS). Coronaviruses have been implicated in the etiology of MS. The objective of the present study was to look for coronaviral RNA in AMON, which could be present in the initial stages of the development of MS. MATERIAL AND METHODS: Spinal fluids from 37 patients with AMON and 15 surgical control patients with protrusion of the intervertebral disk were assayed with a nested multiplex polymerase chain reaction with primers specific for human coronaviruses strain (HCV) 229E and OC43. RESULTS: Four patients and 1 control were positive for HCV-229E. No evidence of HCV-OC43 was found. The frequency of positive samples was low and there was no statistical difference between AMON and controls. CONCLUSION: This study does not provide evidence for an etiological role of human coronaviruses in acute monosymptomatic optic neuritis.
Authors:
R B Dessau; G Lisby; J L Frederiksen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  100     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  IM    
Affiliation:
Department of Clinical Microbiology, Herlev University Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Cerebrospinal Fluid / virology*
Coronavirus / genetics,  isolation & purification*
Coronavirus 229E, Human*
Coronavirus Infections / diagnosis*,  virology
Coronavirus OC43, Human*
Female
Humans
Male
Middle Aged
Optic Neuritis / diagnosis*,  virology
RNA / genetics
RNA, Viral / cerebrospinal fluid
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/RNA primers; 0/RNA, Viral; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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