Document Detail

Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis.
MedLine Citation:
PMID:  10442448     Owner:  NLM     Status:  MEDLINE    
Acute monosymptomatic optic neuritis (AMON) may be an initial symptom of multiple sclerosis (MS). Coronaviruses have been implicated in the etiology of MS. The objective of the present study was to look for coronaviral RNA in AMON, which could be present in the initial stages of the development of MS. MATERIAL AND METHODS: Spinal fluids from 37 patients with AMON and 15 surgical control patients with protrusion of the intervertebral disk were assayed with a nested multiplex polymerase chain reaction with primers specific for human coronaviruses strain (HCV) 229E and OC43. RESULTS: Four patients and 1 control were positive for HCV-229E. No evidence of HCV-OC43 was found. The frequency of positive samples was low and there was no statistical difference between AMON and controls. CONCLUSION: This study does not provide evidence for an etiological role of human coronaviruses in acute monosymptomatic optic neuritis.
R B Dessau; G Lisby; J L Frederiksen
Related Documents :
17388988 - Clinical and demographical characteristics of primary progressive multiple sclerosis in...
17984668 - Prevalence and incidence of the metabolic syndrome in the european lacidipine study on ...
3537648 - Multiple sclerosis: decreased relapse rate through dietary supplementation with calcium...
17548448 - Multiple sclerosis in pakistan.
25062878 - Does tobacco influence the natural history of autoimmune pancreatitis?
21663878 - Plasmodium vivax malaria: is it actually benign?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  100     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  IM    
Department of Clinical Microbiology, Herlev University Hospital, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Cerebrospinal Fluid / virology*
Coronavirus / genetics,  isolation & purification*
Coronavirus 229E, Human*
Coronavirus Infections / diagnosis*,  virology
Coronavirus OC43, Human*
Middle Aged
Optic Neuritis / diagnosis*,  virology
RNA / genetics
RNA, Viral / cerebrospinal fluid
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/RNA primers; 0/RNA, Viral; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surgical outcome in patients with coexisting multiple sclerosis and spondylosis.
Next Document:  Expression of costimulatory molecules on peripheral blood mononuclear cells in multiple sclerosis.