| Coronary vasospasm secondary to hypercholinergic crisis: an iatrogenic cause of acute myocardial infarction in myasthenia gravis. | |
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MedLine Citation:
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PMID: 16098399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with myasthenia gravis undergo lifelong treatment with anticholinesterase agents. While the heart is usually unaffected by this disease, clinicians should bear in mind the potential adverse interaction between cardiac function and the underlying myasthenic disease or its specific medications. In the present article we report, to the best of our knowledge for the first time in the literature, a case of vasospastic acute myocardial infarction due to iatrogenic hypercholinergic crisis secondary to anticholinesterase therapy in an elderly female with myasthenia gravis. This clinical vignette emphasizes the importance of taking into account the potential vasospastic effect of anticholinesterase drugs. Indeed, prompt recognition of the pathophysiology of myocardial ischemia due to iatrogenic hypercholinergic crisis is pivotal to the timely and appropriate management of this medical emergency, as well as prevention of future recurrences. |
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Authors:
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Gianluca Comerci; Antonino Buffon; Giuseppe G L Biondi-Zoccai; Vito Ramazzotti; Enrico Romagnoli; Marinica Savino; Antonio G Rebuzzi; Luigi M Biasucci; Francesco Loperfido; Filippo Crea |
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Publication Detail:
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Type: Case Reports; Letter |
Journal Detail:
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Title: International journal of cardiology Volume: 103 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2005-12-07 Revised Date: 2006-12-14 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 335-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cholinesterase Inhibitors / adverse effects*, therapeutic use Coronary Angiography Coronary Vasospasm / etiology, physiopathology* Electrocardiography Female Humans Myasthenia Gravis / complications, drug therapy* Myocardial Infarction / etiology, physiopathology* Pyridostigmine Bromide / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 101-26-8/Pyridostigmine Bromide |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2006 Nov 10;113(2):270-1
[PMID:
16318887
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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