Document Detail

Coronary vasomotor response to the selective B1-kinin-receptor agonist Des-Arg9-bradykinin in humans.
MedLine Citation:
PMID:  16446219     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the present study was to assess the effects of selective B1-receptor stimulation with des-Arg9-bradykinin on coronary vasomotion in transplanted and non-transplanted patients. BACKGROUND: Bradykinin B1-receptors have been identified on endothelial and smooth muscle cells in human coronary arteries in vitro; however, their physiologic role in the coronary circulation is unknown. METHODS: Twelve heart transplant patients were compared with 10 control subjects at 3.2 +/- 2.2 months after surgery. Coronary flow velocity was measured using guide-wire Doppler. The diameter of 3 epicardial segments of the left coronary artery and coronary blood flow were assessed at baseline, immediately after infusions of increasing doses of des-arginine(Arg9)-bradykinin at estimated coronary blood concentrations of 5.4 x 10(-9), 5.4 x 10(-8), 5.4 x 10(-7) and 1.6 x 10(-6) mol/liter, and of acetylcholine at 10(-8), 10(-7) and 10(-6) mol/liter). RESULTS: Des-Arg9-bradykinin induced a similar decrease in all measured epicardial diameters in both groups and no change in coronary blood flow. Vasoconstriction was significant only at the 2 highest concentrations: -6 +/- 9% (p < 0.01) and -7 +/- 11% (p < 0.01) in control subjects, and -8 +/- 8% (p < 0.001) and -9 +/- 11% (p < 0.001) in heart transplant patients. Acetylcholine induced significant epicardial vasodilation in control subjects and vasoconstriction in transplant patients. The presence of allograft rejection did not modify the responses to des-Arg9-bradykinin with regard to both conductance and resistance vessels. CONCLUSIONS: Kinin B1-receptors exist and can be stimulated in humans. The vasoconstrictive action on epicardial coronary arteries of des-Arg(9)-bradykinin in humans argues for a predominant action of B1-receptor stimulation at the level of smooth muscle cells.
Eduardo Aptecar; Philippe Lecorvoisier; Emmanuel Teiger; Philippe Garot; Patrick Dupouy; Said Sediame; Emmanuelle Vermes; Daniel Loisance; Luc Hittinger; Jean-Luc Dubois-Rande; Olivier Montagne
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  25     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-31     Completed Date:  2006-08-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-94     Citation Subset:  IM    
Fédération de Cardiologie-Hôpital Henri Mondor, INSERM-U400, Créteil, France.
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MeSH Terms
Acetylcholine / pharmacology
Blood Flow Velocity / drug effects,  physiology
Bradykinin / analogs & derivatives*,  pharmacology
Coronary Angiography
Coronary Vessels / drug effects,  physiology
Dose-Response Relationship, Drug
Endothelium, Vascular / chemistry,  physiology
Heart Transplantation / physiology
Hemodynamics / physiology
Middle Aged
Molsidomine / analogs & derivatives,  pharmacology
Muscle, Smooth, Vascular / chemistry,  physiology
Receptor, Bradykinin B1 / agonists*,  analysis,  physiology*
Receptor, Bradykinin B2 / agonists*,  analysis,  physiology*
Vasoconstriction / drug effects*,  physiology
Vasodilation / drug effects*,  physiology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Receptor, Bradykinin B1; 0/Receptor, Bradykinin B2; 0/Vasodilator Agents; 15958-92-6/bradykinin, des-Arg(9)-; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine; 51-84-3/Acetylcholine; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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