Document Detail

Coronary vasomotor response is related to the angiographic extent of coronary sclerosis in patients with stable angina pectoris.
MedLine Citation:
PMID:  12956627     Owner:  NLM     Status:  MEDLINE    
Disturbed vasomotor function in coronary arteries has clinical importance in early stages of coronary artery disease (CAD), as it may contribute to the potential risk for an ischaemic coronary event. In the present study, we have investigated the relationship between coronary vasomotor function and the extent of CAD. The response to acetylcholine and nitrate infusion was assessed by quantitative coronary angiography. The extent of CAD was categorized into two groups: minor CAD (normal coronary arteries and vessel wall irregularities) and significant CAD (one-, two- and three-vessel disease). A total of 277 patients with stable angina pectoris, referred for a first diagnostic coronary angiography, were eligible for analysis (mean age 57 years, 61% male). The response to nitrate was significantly impaired in patients with significant CAD ( P <0.001). On the other hand, the response to acetylcholine was not different between the two groups ( P =0.12); however, a trend between the response to acetylcholine and the extent of CAD was observed in patients without a previous infarction ( P =0.07), which was a significant interaction variable. Furthermore, a significant relationship between coronary vasomotor response and the number of cardiovascular risk factors was observed ( P <0.05). In conclusion, in a heterogeneous group of patients, coronary vasomotor function measured by nitrate infusion was more strongly associated with the extent of CAD and the number of risk factors than the response to acetylcholine. These data suggest that, in patients with advanced atherosclerosis or multiple risk factors, the vasomotor dysfunction is not solely restricted to the endothelium.
Folkert W Asselbergs; Stefan H J Monnink; Nic J G M Veeger; Ad J van Boven; Paul L van Haelst; Gillian A J Jessurun; Wiek H van Gilst; René A Tio
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  106     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-21     Completed Date:  2004-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  IM    
Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.
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MeSH Terms
Acetylcholine / diagnostic use*
Analysis of Variance
Angina Pectoris / pathology,  physiopathology*,  radiography
Chi-Square Distribution
Coronary Angiography*
Coronary Artery Disease / pathology,  physiopathology*,  radiography
Coronary Vessels / drug effects,  physiopathology*
Infusions, Intravenous
Middle Aged
Nitroglycerin / diagnostic use
Risk Factors
Vasoconstrictor Agents / diagnostic use*
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin

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