| Coronary vasomotor and blood flow responses to isoflavone-intact soya protein in subjects with coronary heart disease or risk factors for coronary heart disease. | |
| | |
MedLine Citation:
|
PMID: 18442357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Results in animals suggest favourable coronary vasomotor actions of isoflavones; however, the effects of isoflavones on the human coronary circulation have not been determined. In the present study, we therefore investigated the effects of short-term isoflavone-intact soya protein ingestion on basal coronary arterial tone and stimulated vasoreactivity and blood flow in patients with CHD (coronary heart disease) or risk factors for CHD. Seventy-one subjects were randomized, double-blind, to isoflavone-intact soya protein [active; n=33, aged 58+/-8 years (mean+/-S.D.)] or isoflavone-free placebo (n=38, aged 61+/-8 years) for 5 days prior to coronary angiography. In 25 of these subjects, stimulated coronary blood flow was calculated from flow velocity, measured using intracoronary Doppler and coronary luminal diameter before and after intracoronary adenosine, ACh (acetylcholine) and ISDN (isosorbide dinitrate) infusions. Basal and stimulated coronary artery luminal diameters were measured using quantitative coronary angiography. Serum concentrations of the isoflavones genistein, daidzein and equol were increased by active treatment (P<0.001, P<0.001 and P=0.03 respectively). Basal mean luminal diameter was not significantly different between groups (active compared with placebo: 2.9+/-0.7 compared with 2.73+/-0.44 mm, P=0.31). There was no difference in luminal diameter, flow velocity and volume flow responses to adenosine, ACh or ISDN between groups. Active supplement had no effect on basal coronary artery tone or stimulated coronary vasoreactivity or blood flow compared with placebo. Our results suggest that short-term consumption of isoflavone-intact soya protein is neither harmful nor beneficial to the coronary circulation of humans with CHD or risk factors for CHD. These results are consistent with recent cautions placed on the purported health benefits of plant sterols. |
| | |
Authors:
|
Carolyn M Webb; Christopher S Hayward; Mark J Mason; Charles D Ilsley; Peter Collins |
Related Documents
:
|
3568297 - In vivo characterization of synthetic thromboxane a2 in canine myocardium. 999367 - Effects of morphine and halothane anesthesia on coronary blood flow. 6506117 - Intravertebral artery adenosine fails to alter cerebral blood flow in the dog. 9420717 - Myocardial technetium 99m-labeled teboroxime clearance derived from canine scans differ... 10064827 - Cerebral blood flow does not mediate the effect of brain temperature on recovery of ext... 1777447 - Miniaturized heart-lung machine. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical science (London, England : 1979) Volume: 115 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-07 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
|
Languages: eng Pagination: 353-9 Citation Subset: IM |
Affiliation:
|
Cardiac Medicine, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK. c.webb@imperial.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Blood Pressure / drug effects Coronary Angiography Coronary Circulation / drug effects* Coronary Disease / blood, diet therapy*, physiopathology Double-Blind Method Female Humans Isoflavones / blood, pharmacology* Lipids / blood Male Middle Aged Regional Blood Flow / drug effects Risk Factors Soybean Proteins / pharmacology* Vascular Resistance / drug effects Vasodilation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
|
0/Isoflavones; 0/Lipids; 0/Soybean Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of theory utilization among prenatal HIV-testing research.
Next Document: Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells.