Document Detail

Coronary vasoconstrictor potential of triptans: a review of in vitro pharmacologic data.
MedLine Citation:
PMID:  15149489     Owner:  NLM     Status:  MEDLINE    
This article reviews the in vitro pharmacology of the triptans in human isolated coronary arteries. As expected, based on their similar pharmacologic profiles, the triptans cannot be easily differentiated with respect to effects at human isolated coronary arteries. Furthermore, the data show that at therapeutically relevant concentrations, triptans have little potential to cause clinically significant constriction of nondiseased coronary arteries. These data, considered in the context of clinical findings reviewed elsewhere in this supplement, support the conclusion that, while all triptans have the potential to produce small contractions of human isolated coronary arteries, their craniovascular selectivity, when used at therapeutic doses, renders them unlikely to cause serious adverse coronary events in patients with healthy coronary arteries.
Antoinette Maassen Van Den Brink; Pramod R Saxena
Related Documents :
11386379 - Myocardial infarction with normal coronary arteries: the pathologic and clinical perspe...
15319709 - Coronary vasospasm and myocardial infarction induced by oral sumatriptan.
18273549 - Coronary myocardial bridge: an innocent bystander?
6613809 - Catheter-induced coronary artery spasm: an angiographic manifestation of vasospastic an...
2297959 - Coronary artery spasm induced by anesthesia: a case report and review of the literature.
18721599 - Coronary artery spasm: a rare but important cause of postoperative myocardial infarction.
25127059 - Large myocardial infarction with myocardium calcium deposits associated with reperfusio...
1244729 - Effects of electrical countershock on serum creatine phosphokinase (cpk) isoenzyme acti...
6545739 - Classification of mitral valve prolapse.
Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  Headache     Volume:  44 Suppl 1     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-19     Completed Date:  2004-08-04     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S13-9     Citation Subset:  IM    
Department of Pharmacology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Disease / chemically induced
Coronary Vessels / drug effects*
Migraine Disorders / drug therapy
Receptors, Serotonin / drug effects
Serotonin Agonists / adverse effects,  pharmacology*
Vasoconstriction / drug effects*
Vasoconstrictor Agents / adverse effects,  pharmacology*
Reg. No./Substance:
0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Vasoconstrictor Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Are migraine and coronary heart disease associated? An epidemiologic review.
Next Document:  Cardiovascular tolerability and safety of triptans: a review of clinical data.