| Coronary vascular smooth muscle function in E. coli endotoxemia in dogs. | |
| | |
MedLine Citation:
|
PMID: 2000978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to determine whether intrinsic contraction-relaxation properties of coronary arteries are altered during acute gram-negative endotoxemia. Coronary vascular smooth muscle (VSM) was evaluated in vitro using large and small left circumflex coronary ring preparations isolated from dogs 4 h after administration of either saline (control; C) or 1.5 mg/kg Escherichia coli endotoxin (ET). ET dogs exhibited marked systemic hypotension and cardiovascular depression throughout the 4-h in vivo phase of the study accompanied by reduction in total left ventricular myocardial blood flow. Isolated coronary vessels were stretched to the apex of the length-contractile tension curve; no differences were observed in length-active or length-passive tension (vessel compliance) relationships between C and ET vessels. Isometric contractions produced by K+ and prostaglandin F2 alpha (PGF2 alpha) were similar in C and ET coronary arteries. VSM relaxant responses to nitroprusside (NP; 10(-10) to 10(-4) M) were also similar in C and ET vessels. In contrast to the apparent lack of effect of ET on directly acting VSM agents, relaxation responses to the endothelial-dependent vasodilator acetylcholine (ACh) were significantly less in ET vessels. Impaired vasodilator response to ACh was not improved by in vivo treatment with the combination antioxidant therapy of allopurinol, superoxide dismutase, and catalase. We conclude that both depolarization (K+) and receptor (PGF2 alpha)-mediated contractile mechanisms, as well as basal cGMP (NP)-mediated vasodilator mechanisms, remained functional in coronary vasculature during acute endotoxemia. Inhibition of ACh-mediated relaxation in ET vessels suggests altered endothelial-dependent vasodilation in coronary arteries during endotoxemia, but this change did not seem to be associated causally with oxygen free radicals. |
| | |
Authors:
|
J L Parker; R S Keller; D V DeFily; M H Laughlin; M J Novotny; H R Adams |
Related Documents
:
|
1714008 - Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation. 3431598 - Paf-acether induced cardiac dysfunction in the isolated perfused guinea pig heart. 22783288 - Subclinical atherosclerosis in northern and southern china: the chinese paradox. 12975258 - Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impa... 16140588 - Relations of longitudinal left ventricular systolic function to left ventricular mass, ... 22103748 - Underuse of antithrombotic therapy caused high incidence of ischemic stroke in patients... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 260 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Mar |
Date Detail:
|
Created Date: 1991-04-11 Completed Date: 1991-04-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H832-41 Citation Subset: IM |
Affiliation:
|
John M. Dalton Research Center, University of Missouri, Columbia 65211. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
pharmacology Animals Coronary Vessels / drug effects, pathology, physiopathology* Dinoprost / pharmacology Dogs Endotoxins / blood* Escherichia coli* Free Radical Scavengers Male Muscle, Smooth, Vascular / drug effects, physiopathology* Nitroprusside / pharmacology Potassium Chloride / pharmacology Vasoconstriction Vasodilation |
| Grant Support | |
ID/Acronym/Agency:
|
HL-36079/HL/NHLBI NIH HHS; HL-36531/HL/NHLBI NIH HHS; K04-HL-01169/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Endotoxins; 0/Free Radical Scavengers; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine; 551-11-1/Dinoprost; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of adrenalectomy or sympathectomy on spinal cord blood flow in hypothermic rats.
Next Document: Power spectral analysis of blood pressure variability in traumatic quadriplegic humans.