Document Detail

Coronary vascular reactivity after acute myocardial ischemia.
MedLine Citation:
PMID:  7123259     Owner:  NLM     Status:  MEDLINE    
Exogenous thrombin produced a biphasic response (a potent dose-related vasodilatation followed by vasoconstriction) in nonischemic canine coronary arteries. The vasodilatation was not blocked by propranolol, atropine, or indomethacin, but was completely blocked by heparin or denudation of the intimal endothelial cells. A similar loss of vasodilating response to thrombin occurred in ischemic coronary arteries with a concomitant enhancement of vasoconstriction. This study indicates that altered responses to thrombin in coronary arteries with damaged endothelium may play an important role in the pathogenesis of coronary vasospasm.
D D Ku
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  218     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  576-8     Citation Subset:  IM    
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MeSH Terms
Coronary Circulation / drug effects*
Coronary Disease / physiopathology*
Endothelium / drug effects
Muscle, Smooth, Vascular / physiopathology*
Myocardial Infarction / physiopathology*
Thrombin / pharmacology*
Vasoconstriction / drug effects
Vasomotor System / drug effects
Verapamil / pharmacology
Grant Support
Reg. No./Substance:
52-53-9/Verapamil; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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