| Coronary vascular reactivity after acute myocardial ischemia. | |
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MedLine Citation:
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PMID: 7123259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exogenous thrombin produced a biphasic response (a potent dose-related vasodilatation followed by vasoconstriction) in nonischemic canine coronary arteries. The vasodilatation was not blocked by propranolol, atropine, or indomethacin, but was completely blocked by heparin or denudation of the intimal endothelial cells. A similar loss of vasodilating response to thrombin occurred in ischemic coronary arteries with a concomitant enhancement of vasoconstriction. This study indicates that altered responses to thrombin in coronary arteries with damaged endothelium may play an important role in the pathogenesis of coronary vasospasm. |
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Authors:
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D D Ku |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 218 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1982-12-03 Completed Date: 1982-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 576-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects* Coronary Disease / physiopathology* Dogs Endothelium / drug effects Male Muscle, Smooth, Vascular / physiopathology* Myocardial Infarction / physiopathology* Thrombin / pharmacology* Vasoconstriction / drug effects Vasomotor System / drug effects Verapamil / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-24485/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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52-53-9/Verapamil; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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