| Coronary vascular injury following transient coronary artery occlusion: prevention by pretreatment with deferoxamine, dimethylthiourea and N-2-mercaptoproprionyl glycine. | |
| | |
MedLine Citation:
|
PMID: 8371155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of oxygen-derived free radicals as initiators of vascular dysfunction observed 24 hr after transient coronary artery occlusion (15 or 30 min) was examined in the anesthetized dog. A 15-min occlusion increased human serum (HSA) albumin extravasation within anterior myocardium without producing myocardial necrosis or edema. Minimal leukocyte uptake and free radical formation were present at 24 hr. 2-Mercaptoproprionyl glycine (MPG) (a free radical scavenger), deferoxamine (a chelator of ferrous ions) and dimethylthiourea (a hydroxyl ion scavenger), administered 15 min before coronary artery occlusion and extending 1.5 hr into reperfusion, reduced HSA uptake within anterior myocardium. A different pattern of injury was present after a 30-min occlusion. Subendocardial necrosis (1.2 +/- 0.8 g), edema, HSA extravasation and leukocyte uptake were observed at 24 hr. MPG failed to reduce the extent of necrosis, HSA extravasation, edema, leukocyte uptake or free radical formation. HSA extravasation, leukocyte uptake, tissue edema and free radical formation present 24 hr after a 30-min occlusion were reduced by acute deferoxamine and dimethylthiourea, but not by acute MPG administration. The failure of MPG to reduce HSA extravasation observed 24 hr after a 30-min coronary artery occlusion was associated with both leukocyte uptake and continued free radical formation, whereas dimethylthiourea and deferoxamine reduced leukocyte uptake, free radical formation and HSA extravasation. |
| | |
Authors:
|
E Patterson |
Related Documents
:
|
2268795 - Angiographic features associated with acute coronary artery occlusion during elective a... 8541665 - Sterilization with methyl cyanoacrylate-induced fallopian tube occlusion from a nonsurg... 1416395 - Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necr... 9747155 - Hand-arm vibration syndrome with proximal ulnar artery occlusion. 10084675 - Vascular endothelial growth factor in porcine coronary arteries following balloon angio... 16153275 - Extrafascially harvested radial artery in cabg: technique of harvest, complications, an... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of pharmacology and experimental therapeutics Volume: 266 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1993 Sep |
Date Detail:
|
Created Date: 1993-10-14 Completed Date: 1993-10-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1528-35 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, University of Oklahoma Health Sciences Center, Oklahoma City. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Capillary Permeability Coronary Disease / etiology, metabolism, prevention & control* Coronary Vessels / drug effects, physiology Deferoxamine / therapeutic use* Dogs Lipid Peroxidation Myocardial Reperfusion Injury / metabolism, prevention & control Myocardium / metabolism Reactive Oxygen Species / metabolism Serum Albumin / pharmacokinetics Thiopronine / therapeutic use* Thiourea / analogs & derivatives*, therapeutic use Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
GM-36512/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Reactive Oxygen Species; 0/Serum Albumin; 1953-02-2/Thiopronine; 61805-96-7/1,3-dimethylthiourea; 62-56-6/Thiourea; 70-51-9/Deferoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tonic tone in arteries exposed continuously to angiotensin II in vitro.
Next Document: [3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective li...