| Coronary vascular effects of endothelin-1 during arterial hypotension. | |
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MedLine Citation:
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PMID: 8587366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin-1 (ET-1) effects on left circumflex coronary artery (LCCA) flow, systemic arterial pressure, heart rate, and left ventricle (LV) pressure and dP/dt were recorded in five anesthetized goats under control conditions and during arterial hypotension. Hypotension, induced by mechanical constriction of the inferior vena cava, reduced mean systemic arterial pressure from 92 +/- 4 to 59 +/- 4 mm Hg (p < 0.002), LCCA flow from 26 +/- 4 to 17 +/- 3 ml/min (p < 0.01), systolic LV pressure from 108 +/- 2.5 to 79 +/- 2 mm Hg (p < 0.002), and peak systolic LV dP/dt from 1,500 +/- 106 to 990 +2- 130 mm Hg/s (p < 0.02). Heart rate did not change (p > 0.05). ET-1 (0.01-0.1 nmol) injected into LCCA reduced LCCA flow in a dose-dependent manner without affecting the other variables recorded during control periods (C) and hypotension (H). The percentage reductions of LCCA flow by ET-1 were: for 0.01 nmol, 4.5 +/- 2 (C) vs. 11 +/- 2 (H) (p < 0.05); for 0.03 nmol, 15 +/- 2 (C) vs. 32 +/- 4 (H) (p < 0.05); and for 0.1 nmol, 44 +/- 5 (C) vs. 67 +/- 5 (H) (p < 0.05). This indicates that the coronary vasoconstrictor effects of ET-1 are increased during hypotension. Therefore, heart ischemia may be aggravated in situations of arterial hypotension with increased plasma concentrations of ET-1. |
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Authors:
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N Fernández; A L García-Villalón; L Monge; B Gómez; G Diéguez |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 26 Suppl 3 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1995 |
Date Detail:
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Created Date: 1996-03-28 Completed Date: 1996-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S214-5 Citation Subset: IM |
Affiliation:
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Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / drug effects*, physiology Endothelins / blood, pharmacology* Female Goats Hypotension / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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