Document Detail

Coronary thrombus in patients undergoing primary PCI for STEMI: Prognostic significance and management.
MedLine Citation:
PMID:  24976910     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Acute ST-elevation myocardial infarction (STEMI) usually results from coronary atherosclerotic plaque disruption with superimposed thrombus formation. Detection of coronary thrombi is a poor prognostic indicator, which is mostly proportional to their size and composition. Particularly, intracoronary thrombi impair both epicardial blood flow and myocardial perfusion, by occluding major coronary arteries and causing distal embolization, respectively. Thus, although primary percutaneous coronary intervention is the preferred treatement strategy in STEMI setting, the associated use of adjunctive antithrombotic drugs and/or percutaneous thrombectomy is crucial to optimize therapy of STEMI patients, by improving either angiographical and clinical outcomes. This review article will focus on the prognostic significance of intracoronary thrombi and on current antithrombotic pharmacological and interventional strategies used in the setting of STEMI to manage thrombotic lesions.
Sabine Vecchio; Elisabetta Varani; Tania Chechi; Marco Balducelli; Giuseppe Vecchi; Matteo Aquilina; Giulia Ricci Lucchi; Alessandro Dal Monte; Massimo Margheri
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of cardiology     Volume:  6     ISSN:  1949-8462     ISO Abbreviation:  World J Cardiol     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-30     Completed Date:  2014-06-30     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  101537090     Medline TA:  World J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-92     Citation Subset:  -    
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