Document Detail

Coronary thrombolysis with human single-chain, urokinase-type plasminogen activator (pro-urokinase) in patients with acute myocardial infarction.
MedLine Citation:
PMID:  3080936     Owner:  NLM     Status:  MEDLINE    
Single-chain, urokinase-type plasminogen activator (pro-urokinase), isolated from the conditioned medium of a human renal adenocarcinoma cell line, was administered to six patients with evolving myocardial infarction of less than 5 hours' duration and angiographically confirmed total occlusion of the infarct-related coronary artery. The agent was infused intravenously at a rate of 40 mg over 60 minutes immediately followed in three patients by intracoronary infusion of 20 mg over 30 minutes. In four of the six patients complete reperfusion was obtained during intravenous administration and in one patient after 20 minutes of intracoronary infusion. One patient did not respond. The infusion caused significant changes in the fibrinogen level and generation of fibrinogen breakdown products in only one patient. Single-chain, urokinase-type plasminogen activator can induce clot-selective coronary thrombolysis in patients with acute myocardial infarction.
F Van de Werf; M Nobuhara; D Collen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of internal medicine     Volume:  104     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-03-17     Completed Date:  1986-03-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  345-8     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Vessels
Fibrin Fibrinogen Degradation Products / metabolism
Fibrinogen / metabolism
Infusions, Intra-Arterial
Infusions, Parenteral
Middle Aged
Myocardial Infarction / blood,  drug therapy*
Plasminogen Activators / therapeutic use*
Urokinase-Type Plasminogen Activator / therapeutic use*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 9001-32-5/Fibrinogen; EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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