| Coronary thrombolysis with human single-chain, urokinase-type plasminogen activator (pro-urokinase) in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 3080936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Single-chain, urokinase-type plasminogen activator (pro-urokinase), isolated from the conditioned medium of a human renal adenocarcinoma cell line, was administered to six patients with evolving myocardial infarction of less than 5 hours' duration and angiographically confirmed total occlusion of the infarct-related coronary artery. The agent was infused intravenously at a rate of 40 mg over 60 minutes immediately followed in three patients by intracoronary infusion of 20 mg over 30 minutes. In four of the six patients complete reperfusion was obtained during intravenous administration and in one patient after 20 minutes of intracoronary infusion. One patient did not respond. The infusion caused significant changes in the fibrinogen level and generation of fibrinogen breakdown products in only one patient. Single-chain, urokinase-type plasminogen activator can induce clot-selective coronary thrombolysis in patients with acute myocardial infarction. |
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Authors:
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F Van de Werf; M Nobuhara; D Collen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of internal medicine Volume: 104 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-03-17 Completed Date: 1986-03-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 345-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Vessels Female Fibrin Fibrinogen Degradation Products / metabolism Fibrinogen / metabolism Humans Infusions, Intra-Arterial Infusions, Parenteral Male Middle Aged Myocardial Infarction / blood, drug therapy* Plasminogen Activators / therapeutic use* Urokinase-Type Plasminogen Activator / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 9001-32-5/Fibrinogen; EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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