Document Detail

Coronary and systemic vascular response to inspiratory resistive breathing.
MedLine Citation:
PMID:  1568985     Owner:  NLM     Status:  MEDLINE    
To evaluate the coronary and systemic cardiovascular response to graded inspiratory resistive breathing, seven dogs were studied 2-4 wk after chronic instrumentation to measure circumflex coronary artery and ascending aortic blood flows as well as aortic and left ventricular (LV) blood pressures. The experiments were performed under chloralose anesthesia (to exclude any confounding emotional effects by dyspnea on cardiovascular variables) and hyperoxic conditions (to prevent chemoreflex activation by hypoxemia). In a randomized fashion, the dogs were subjected to graded inspiratory resistive breathing (spontaneous breathing alone and moderate and severe resistive loading, corresponding to resistances of approximately 0, 40, and 110 cmH2O.s.l-1, respectively). Each run lasted 10 min. Compared with mechanical ventilation with the respiratory muscles at rest, spontaneous breathing alone and moderate and severe inspiratory resistive loading induced pronounced and significant increases in circumflex coronary blood flow (19, 32, and 62%, respectively), which were almost exclusively accounted for by significant decrements in coronary vascular resistance and were paralleled (r = 0.88, P less than 0.0001) by significant increments (18, 31, and 57%) in heart rate transmural-aortic pressure product, an indicator of LV myocardial O2 demand. An increase in myocardial O2 consumption during resistive breathing was confirmed by analysis of coronary sinus blood samples in additional experiments (n = 3). Cardiac output significantly increased (10, 14, and 35%) because of increases in heart rate (15, 24, and 49%), with LV stroke volume and diastolic dimensions remaining unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
J Peters; P Ihle
Related Documents :
2142125 - Normalization of impaired coronary circulation in hypertrophied rat hearts.
9888255 - Effects of cp-060s, a novel cardioprotective drug, on cardiac function and myocardial o...
8997295 - Coronary vascular and endothelial reactivity changes in transgenic mice overexpressing ...
1991345 - Tone-dependent waterfall behavior during venous pressure elevation in isolated canine h...
24061545 - Arterial stiffness/central hemodynamics, renal function, and development of hypertensio...
9391995 - Hormone replacement therapy and intraocular pressure.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  72     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-27     Completed Date:  1992-05-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  905-13     Citation Subset:  IM; S    
Abteilungen für Experimentelle, Heinrich-Heine-Universität Düsseldorf, Federal Republic of Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Airway Resistance / physiology*
Coronary Circulation / physiology*
Hemodynamics / physiology*
Oxygen Consumption
Respiratory Mechanics / physiology*
Vascular Resistance / physiology
Vasodilation / physiology
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fetal and maternal body temperatures measured by radiotelemetry in near-term sheep during thermal st...
Next Document:  Effects of acute exercise intensity on plasma lipids and apolipoproteins in trained runners.