| Coronary structure and perfusion in health and disease. | |
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MedLine Citation:
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PMID: 18559321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood flow is distributed through the heart muscle via a system of vessels forming the coronary circulation. The perfusion of the myocardium can be hampered by atherosclerosis creating localized obstructions in the epicardial vessels or by microvascular disease. In early stages of the disease, these impediments to blood flow are offset by dilation of the resistance vessels, which normally compensates for a decrease in perfusion pressure or increased metabolism. However, this dilatory reserve can become exhausted, which in general occurs first at the deeper layers of the heart wall where intramural vessels are subjected to compressive forces related to heart contraction. In the catheterization laboratory, guide wires of 0.33 mm diameter are available that are equipped with a pressure and flow velocity sensor at the tip, which can be positioned distal to the stenosis. These signals provide information about the impediment of the stenosis on coronary flow and allow for the evaluation of the status of the microcirculation. However, the interpretation of these signals is strongly model-dependent and therefore it is of paramount importance to develop realistic models reflecting the anatomy and unique physiology of the coronary circulation. |
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Authors:
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Jos Spaan; Christina Kolyva; Jeroen van den Wijngaard; Rene ter Wee; Pepijn van Horssen; Jan Piek; Maria Siebes |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Volume: 366 ISSN: 1364-503X ISO Abbreviation: Philos Trans A Math Phys Eng Sci Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-09-30 Revised Date: 2013-04-24 |
Medline Journal Info:
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Nlm Unique ID: 101133385 Medline TA: Philos Trans A Math Phys Eng Sci Country: England |
Other Details:
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Languages: eng Pagination: 3137-53 Citation Subset: IM |
Affiliation:
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Department of Medical Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. j.a.spaan@amc.uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Pressure Computer Simulation Coronary Circulation* Diagnosis, Computer-Assisted / trends Heart / anatomy & histology* Heart Diseases / diagnosis, pathology, physiopathology Humans Models, Anatomic Models, Cardiovascular* Myocardial Contraction Pericardium / physiology Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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