| Coronary steal-induced increase in myocardial infarct size after pharmacologic coronary vasodilation. | |
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MedLine Citation:
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PMID: 7386397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was performed to determine if maximal coronary arterial vasodilation of nonischemic areas would produce an increase in myocardial infarct size through a "steal" of collateral flow from an ischemic region. Myocardial infarction was produced by a 2 hour occlusion and reperfusion of the distal left anterior descending coronary artery in anesthetized dogs. Five minutes after occlusion, 7 dogs were given saline solution, and in 12 dogs the coronary vasodilator chromonar (8 mg/kg, intravenously) was administered. Chromonar produced a significant increase (p less than 0.05) in blood flow to nonischemic regions and a concomitant decrease in flow to ischemic areas. Associated with these changes in flow was an elevation in total release and peak plasma creatine kinase compared with values in saline-treated control dogs. Myocardial infarct size determined with nitroblue tetrazolium stanining was significantly increased (p less than 0.05). These demonstarte that maximal coronary vasodilation of nonischemic areas can result in an extension of myocardial infarction by a steal of collateral flow away from the ischemic region. |
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Authors:
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D C Warltier; G J Gross; H L Brooks |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of cardiology Volume: 46 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1980 Jul |
Date Detail:
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Created Date: 1980-08-28 Completed Date: 1980-08-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 83-90 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / physiopathology Chromonar / pharmacology* Collateral Circulation / drug effects Coronary Circulation* Coronary Vessels / physiopathology Coumarins / pharmacology* Creatine Kinase / blood Dogs Hemodynamics Male Myocardial Infarction / physiopathology* Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Coumarins; 804-10-4/Chromonar; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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