Document Detail


Coronary risk factors used to predict coronary artery disease by logistic regression analysis.
MedLine Citation:
PMID:  1479644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Risk factor analysis in coronary artery disease was conducted in 303 patients who underwent coronary arteriography to identify associations between personal characteristics and the prevalence of coronary heart disease. Age, sex, obesity, smoking, alcohol intake, hypertension, diabetes mellitus, serum uric acid, total cholesterol, LDL- and HDL-cholesterol, triglyceride, and atherogenic indices were statistically analyzed. All 13 variables were first compared between patients with positive and negative ergonovine tests. Only total cholesterol was significantly different, while significant differences in age, sex, history of diabetes, total cholesterol, LDL- and HDL-cholesterol, triglyceride and atherosclerotic indices were observed between patients with and without organic coronary artery stenosis. A multivariate analysis was performed, and the resulting equation was tested using the remaining patients. Logistic analysis of all 13 variables identified 5 (age, sex, diabetes mellitus, LDL- and HDL-cholesterol) which accounted for the differences between patients with and without significant coronary artery disease and that were validated in the test group. The sensitivity for prediction of coronary artery disease was 75.8%, specificity 68.5%, and predictive accuracy 71.5% in the test group. Thus, risk factor analysis appears to be very valuable in screening subjects with high-risk organic coronary stenosis and in optimizing the preventive and therapeutic modalities, but not in predicting vasospastic subjects.
Authors:
H Kambara; A Imoto; C Owada; S Tamaki; T Fudo; S Maetani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  56     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-05     Completed Date:  1993-02-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1199-205     Citation Subset:  IM    
Affiliation:
College of Medical Technology, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Cholesterol / blood
Coronary Angiography
Coronary Artery Disease / diagnosis
Coronary Disease / diagnosis*,  etiology
Coronary Vasospasm / diagnosis
Exercise Test
Female
Humans
Male
Middle Aged
Obesity
Regression Analysis
Risk Factors
Smoking
Chemical
Reg. No./Substance:
57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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