Document Detail

Coronary risk factors, development of myocardial infarction, and plasma oestrogens: a prospective case-control study in men.
MedLine Citation:
PMID:  2746154     Owner:  NLM     Status:  MEDLINE    
A number of studies have reported hyperoestrogenaemia in men surviving an acute myocardial infarction (AMI). This has led to speculations that hyperoestrogenaemia might be a coronary risk factor. It is not clear why plasma levels of oestrogens should be elevated in coronary heart disease. To ascertain whether hyperoestrogenaemia might be present before the onset of a myocardial infarction, we performed a prospective study in 252 men above the age of forty who within the following 5 years suffered an AMI and, as controls, 526 men matched for age and coronary risk factors and 329 randomly selected men. Mean plasma concentrations of oestradiol and oestrone did not differ significantly between the groups. This suggests that hyperoestrogenaemia is not a coronary risk factor and thus, if present after the AMI, is more likely develop concurrently with the myocardial infarction.
E Eldrup; P Winkel; J Lindholm; M W Bentzon; G Jensen; P Schnohr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  225     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-08-15     Completed Date:  1989-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  IM    
Department of Internal Medicine and Endocrinology, Herlev University Hospital, Copenhagen, Denmark.
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MeSH Terms
Estradiol / blood
Estrogens / blood*
Estrone / blood
Middle Aged
Myocardial Infarction / blood,  etiology*,  mortality
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Estrogens; 50-28-2/Estradiol; 53-16-7/Estrone

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