Document Detail


Coronary risk factor profile and prognostic factors for young Japanese patients undergoing coronary revascularization.
MedLine Citation:
PMID:  19531902     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The prevalence of coronary artery disease (CAD) is increasing in young adults. Risk factor profiling will help to prevent heart attacks in young patients. This study aimed to analyze the risk factor profile and predictors of major cardiovascular events (MACE) in young CAD patients. METHODS AND RESULTS: From the Coronary REvascularization Demonstrating Outcome study in the Kyoto (CREDO-Kyoto) registry of Japanese patients undergoing their first coronary revascularization, 6,320 patients with complete data for all variables for statistical analyses were divided into younger (< or =55 years; n=898; 14.3%) and older (>55 years; n=5,422; 85.7%) patients. The risk factors that were more prevalent in the younger patients than in the older patients included: male sex, body mass index of >25 kg/m(2), current smoker, family history of CAD, dyslipidemia and metabolic syndrome-like risk factor accumulation. Multivariate analyses revealed that chronic kidney disease (CKD) was the only significant predictor of MACE, the composite of cardiovascular death, myocardial infarction and cerebrovascular accident, in the younger patients. Importance of CKD as a prognostic factor was consistently shown by a multivariate analysis in the older patients. CONCLUSIONS: Accumulation of multiple risk factors is prevalent and CKD is associated with MACE in young Japanese CAD patients.
Authors:
Yutaka Furukawa; Natsuhiko Ehara; Ryoji Taniguchi; Yoshisumi Haruna; Neiko Ozasa; Naritatsu Saito; Takahiro Doi; Kozo Hoshino; Toshihiro Tamura; Satoshi Shizuta; Mitsuru Abe; Masanao Toma; Takeshi Morimoto; Satoshi Teramukai; Masanori Fukushima; Toru Kita; Takeshi Kimura;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-16
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1459-65     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan. furukawa@kcgh.gr.jp
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Age Factors
Asian Continental Ancestry Group
Chronic Disease
Coronary Artery Disease / diagnosis*,  epidemiology,  etiology
Female
Humans
Japan / epidemiology
Kidney Diseases / complications
Male
Middle Aged
Multivariate Analysis
Myocardial Revascularization / adverse effects*
Prognosis
Risk Factors
Investigator
Investigator/Affiliation:
Jong-Dae Lee / ; Kuniyoshi Tanaka / ; Katsuo Okazaki / ; Masaaki Takahashi / ; Teiji Oda / ; Shigeo Matsui / ; Naohiro Ohashi / ; Eiichi Matsuyama / ; Makoto Kadoya / ; Yoshiki Takatsu / ; Shinichi Nomoto / ; Kazuaki Kataoka / ; Hajime Kotoura / ; Masaki Aota / ; Akira Miura / ; Satoru Suwa / ; Chuwa Tei / ; Ryuzo Sakata / ; Shuichi Hamasaki / ; Hiroyuki Yamamoto / ; Takeshi Aoyama / ; Takahiro Sakurai / ; Mitsuo Matsuda / ; Masahiko Onoe / ; Yuzo Takeuchi / ; Ryuji Nohara / ; Kimisato Nakano / ; Yutaka Furukawa / ; Shigefumi Morioka / ; Yukikatsu Okada / ; Kenichi Shiratori / ; Yasuki Kihara / ; Michihiro Nasu / ; Satoshi Teramukai / ; Masanori Fukushima / ; Masakiyo Nobuyoshi / ; Hitoshi Okabayashi / ; Hitoshi Yasumoto / ; Jyota Nakano / ; Tomoyuki Murakami / ; Katsuya Ishida / ; Hisao Ogawa / ; Michio Kawasuji / ; Seigo Sugiyama / ; Shoichiro Hagiwara / ; Kazuaki Mitsudo / ; Tatsuhiko Komiya / ; Kazushige Kadota / ; Takeshi Kimura / ; Masashi Komeda / ; Takeshi Morimoto / ; Ryozo Tatami / ; Teruaki Ushijima / ; Akira Yoshida / ; Hiroyuki Nakajima / ; Shinji Miki / ; Ryuichi Hattori / ; Noboru Nishiwaki / ; Manabu Shirotani / ; Hiroshi Kato / ; Hiroshi Eizawa / ; Masaru Tanaka / ; Kazuaki Minami / ; Minoru Horie / ; Tohru Asai / ; Hiroyuki Takashima / ; Ryuji Higashita / ; Mamoru Takahashi / ; Takafumi Tahata / ; Yoshiki Matoba / ; Kiyoshi Doyama / ; Makoto Araki / ; Akinori Takizawa / ; Mitsuomi Shimamoto / ; Fumio Yamazaki / ; Osamu Doi / ; Hirofumi Kambara / ; Katsuhiko Matsuda / ; Satoshi Kaburagi / ; Masafumi Nara / ; Masaki Kawanami / ; Takashi Konishi / ; Yoshihisa Nakagawa / ; Kazunobu Nishimura / ; Seiji Ootani / ; Takaaki Sugita / ; Kumiko Kitagawa / ; Hiromi Yoshida / ; Misato Yamauchi / ; Asuka Saeki / ; Chikako Hibi / ; Emi Takinami / ; Izumi Miki / ; Miya Hanazawa / ; Naoko Okamoto / ; Sachiko Maeda / ; Saeko Minematsu / ; Saori Tezuka / ; Yuki Sato / ; Yumika Fujino / ; Hitomi Sasae / ; Rei Fujita / ; Ayu Motofusa / ; Takami Hiraoka / ; Ayumi Yamamoto / ; Miho Hayashikawa / ; Yoko Fujiki /

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