Document Detail


Coronary response to diadenosine triphosphate after ischemia-reperfusion in the isolated rat heart.
MedLine Citation:
PMID:  22890026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diadenosine triphosphate (Ap3A) is a vasoactive mediator stored in platelet granules that may be released during coronary ischemia-reperfusion. To study its coronary effects in such circumstances, rat hearts were perfused in a Langendorff preparation and the coronary response to Ap3A (10(-7)-10(-5) mol/L) was recorded. Both at basal coronary resting tone and after precontraction with 11-dideoxy-1a,9a-epoxymethanoprostaglandin F(2)(α) (U46619), Ap3A produced concentration-dependent vasodilation in the heart, which was attenuated following ischemia-reperfusion. Ap3A-induced relaxation was also attenuated in control conditions and after ischemia-reperfusion by the purinergic P2Y antagonist reactive blue 2 (2 × 10(-6) mol/L), the P2Y(1) antagonist MRS 2179 (10(-5) mol/L), the nitric oxide synthesis inhibitor N-omega-nitro-l-arginine methyl ester (l-NAME; 10(-4) mol/L) and the ATP-dependent potassium channel blocker glibenclamide (10(-5) mol/L). These results suggest that Ap3A induces coronary vasodilation, an effect attenuated by ischemia-reperfusion due to the functional impairment of purinergic P2Y receptors and K(ATP) channels, and/or reduced nitric oxide release. This impairment of vasodilation may contribute to the coronary dysregulation that occurs during ischemia-reperfusion.
Authors:
Angel Luis García-Villalón; Nuria Fernández; Luis Monge; Miriam Granado; Gonzalo Carreño-Tarragona; Juan Carlos Figueras; Godofredo Diéguez
Related Documents :
7618616 - Predictive value of hemostatic factors for sudden death in patients with stable angina ...
8225736 - Seasons, temperature and coronary disease.
10084386 - Sudden death in the general population in okinawa: incidence and causes of death.
11337606 - The association between air pollution and heart failure, arrhythmia, embolism, thrombos...
11688566 - Conotruncal myocardium arises from a secondary heart field.
10072236 - Effect of acute testosterone on myocardial ischemia in men with coronary artery disease.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-13
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-10-31     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  966-72     Citation Subset:  IM    
Affiliation:
Departamento de Fisiología, Universidad Autónoma de Madrid, Madrid, Spain. angeluis.villalon@uam.es
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / drug effects*
Dinucleoside Phosphates / metabolism*
Heart / physiopathology*
Ischemia / physiopathology*
Male
Rats
Rats, Sprague-Dawley
Reperfusion*
Vasodilation
Vasodilator Agents / metabolism*
Chemical
Reg. No./Substance:
0/Dinucleoside Phosphates; 0/Vasodilator Agents; 56432-02-1/diadenosine triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Human 6-sulfo LacNAc (slan) dendritic cells have molecular and functional features of an important p...
Next Document:  Caveolin-1 expression during the progression of pulmonary hypertension.