Document Detail

Coronary response to diadenosine triphosphate after ischemia-reperfusion in the isolated rat heart.
MedLine Citation:
PMID:  22890026     Owner:  NLM     Status:  MEDLINE    
Diadenosine triphosphate (Ap3A) is a vasoactive mediator stored in platelet granules that may be released during coronary ischemia-reperfusion. To study its coronary effects in such circumstances, rat hearts were perfused in a Langendorff preparation and the coronary response to Ap3A (10(-7)-10(-5) mol/L) was recorded. Both at basal coronary resting tone and after precontraction with 11-dideoxy-1a,9a-epoxymethanoprostaglandin F(2)(α) (U46619), Ap3A produced concentration-dependent vasodilation in the heart, which was attenuated following ischemia-reperfusion. Ap3A-induced relaxation was also attenuated in control conditions and after ischemia-reperfusion by the purinergic P2Y antagonist reactive blue 2 (2 × 10(-6) mol/L), the P2Y(1) antagonist MRS 2179 (10(-5) mol/L), the nitric oxide synthesis inhibitor N-omega-nitro-l-arginine methyl ester (l-NAME; 10(-4) mol/L) and the ATP-dependent potassium channel blocker glibenclamide (10(-5) mol/L). These results suggest that Ap3A induces coronary vasodilation, an effect attenuated by ischemia-reperfusion due to the functional impairment of purinergic P2Y receptors and K(ATP) channels, and/or reduced nitric oxide release. This impairment of vasodilation may contribute to the coronary dysregulation that occurs during ischemia-reperfusion.
Angel Luis García-Villalón; Nuria Fernández; Luis Monge; Miriam Granado; Gonzalo Carreño-Tarragona; Juan Carlos Figueras; Godofredo Diéguez
Related Documents :
11177676 - The role of pharmacologic treatment to prevent sudden death in the implantable cardiove...
20399566 - Remodeled left ventricular myocardium remote to infarction sites is the arrhythmogenic ...
7968396 - Amniotic fluid embolism as a cause of sudden maternal death.
7242416 - Use of lignocaine and atropine autoinjectors for patients at high risk of sudden death ...
11270706 - Inappropriate shock therapy in a heart failure defibrillator.
16501626 - Bone-marrow-derived progenitor cell therapy in need of proof of concept: design of the ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-13
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-10-31     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  966-72     Citation Subset:  IM    
Departamento de Fisiología, Universidad Autónoma de Madrid, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Vessels / drug effects*
Dinucleoside Phosphates / metabolism*
Heart / physiopathology*
Ischemia / physiopathology*
Rats, Sprague-Dawley
Vasodilator Agents / metabolism*
Reg. No./Substance:
0/Dinucleoside Phosphates; 0/Vasodilator Agents; 56432-02-1/diadenosine triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Human 6-sulfo LacNAc (slan) dendritic cells have molecular and functional features of an important p...
Next Document:  Caveolin-1 expression during the progression of pulmonary hypertension.