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Coronary response to diadenosine tetraphosphate after ischemia-reperfusion in the isolated rat heart.
MedLine Citation:
PMID:  21513710     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Diadenosine tetraphosphate (AP4A) is a vasoactive mediator that may be released from platelet granules and that may reach higher plasma concentrations during coronary ischemia-reperfusion. The objective of this study was to analyze its coronary effects in such conditions. To this, rat hearts were perfused in a Langendorff preparation and the coronary response to Ap4A (10(-7)-10(-5)M) was recorded. In control hearts, Ap4A produced concentration-dependent vasodilatation both at the basal coronary resting tone and after precontracting coronary vasculature with 11-dideoxy-1a,9a-epoxymethanoprostaglandin F(2α) (U46619), and this vasodilatation was reduced by reactive blue 2 (2×10(-6)M), glibenclamide (10(-5)M), H89 (10(-6)M), U73122 (5×10(-6)M) and endothelin-1 (10(-9)M), but not by L-NAME (10(-4)M), isatin (10(-4)M), GF109203x (5×10(-7)M), or wortmannin (5×10(-7)M). After ischemia-reperfusion, the vasodilatation to Ap4A diminished, both in hearts with basal or increased vascular tone, and in this case the relaxation to Ap4A was not modified by reactive blue 2, L-NAME, glibenclamide, isatin, H89, GF109203x or wortmannin, although it was reduced by U73122 and endothelin-1. UTP produced coronary relaxation that was also reduced after ischemia-reperfusion. These results suggest that the coronary relaxation to Ap4A is reduced after ischemia-reperfusion, and that this reduction may be due to impaired effects of K(ATP) channels and to reduced response of purinergic P2Y receptors.
Authors:
Angel Luis García-Villalón; Nuria Fernández; Luis Monge; Godofredo Diéguez
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-15
Journal Detail:
Title:  European journal of pharmacology     Volume:  -     ISSN:  1879-0712     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
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