| Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy. | |
MedLine Citation:
|
PMID: 17574929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High plasma homocysteine (Hcy) has been linked to impaired endothelial function. We investigated whether treatment with pravastatin affects the Hcy levels. Moreover, we studied whether the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism affects coronary vasomotion at baseline and during the treatment with pravastatin. Fifty-one healthy, mildly hypercholesterolemic men (mean age 35+/-4 years) attended this randomised, double-blind, placebo-controlled study. The volunteers were randomised into groups with 6-month treatment with pravastatin (40 mg/day, n=25) or placebo (n=26). Coronary blood flow measurements with positron emission tomography at rest and during adenosine infusion as well as biochemical analyses were done at baseline and at the end of the treatment period. The Hcy concentration decreased significantly during the pravastatin therapy (-0.81+/-1.46 micromol/l, p=0.01), but not during placebo (0.02+/-2.39 micromol/l, p=0.97). The MTHFR polymorphism did not affect the Hcy concentration or coronary flow indices. Neither did the MTHFR polymorphism modulate the effects of pravastatin on coronary vasomotion. In conclusion, a 6-month therapy with pravastatin decreases Hcy concentration in Finnish healthy young men. The MTHFR genotype is neither a determinant of baseline coronary flow indices nor does it modulate the effect of pravastatin on coronary reactivity. |
Authors:
|
Tuomo Nieminen; Juhani Knuuti; Päivi Hämelahti; Mika Kähönen; Reijo Laaksonen; Tuula Janatuinen; Risto Vesalainen; Pirjo Nuutila; Hannu Jokela; Terho Lehtimäki |
Related Documents
:
|
144289 - Changes of regional myocardial blood flow during and after acute focal experimental isc... 20852039 - Adenine nucleotide control of coronary blood flow during exercise. 431099 - Optimization of coronary perfusion rate during cardiac surgery in man. 7192859 - Independent regulation of atrial coronary blood flow by atrial contraction rate in cons... 7059329 - Regional distribution of cardiac output in unanesthetized baboons during +gz stress wit... 2680149 - Effects of endothelin on the coronary vascular bed in open-chest dogs. 11924899 - Cerebral blood flow and cognitive responses to rivastigmine treatment in alzheimer's di... 10414739 - Use of preoperative autologous blood donation in patients undergoing radical retropubic... 21262239 - Basal sympathetic activity to the microcirculation in tetraplegic man revealed by wavel... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-05-13 |
Journal Detail:
|
Title: Vascular pharmacology Volume: 47 ISSN: 1537-1891 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2007 Aug-Sep |
Date Detail:
|
Created Date: 2007-07-30 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 113-7 Citation Subset: IM |
Affiliation:
|
Department of Pharmacological Sciences, Medical School, FI-33014 University of Tampere, Finland. tuomo.nieminen@iki.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Adult Anticholesteremic Agents / pharmacology*, therapeutic use Coronary Circulation / drug effects*, genetics Double-Blind Method Homocysteine / blood, drug effects*, genetics Humans Hypercholesterolemia / drug therapy* Male Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Polymorphism, Genetic Positron-Emission Tomography Pravastatin / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Anticholesteremic Agents; 454-28-4/Homocysteine; 58-61-7/Adenosine; 81093-37-0/Pravastatin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mapping computerized clinical guidelines to electronic medical records: knowledge-data ontological m...
Next Document: Concordance of Medicaid and pharmacy record data in inner-city children with asthma.