Document Detail

Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy.
MedLine Citation:
PMID:  17574929     Owner:  NLM     Status:  MEDLINE    
High plasma homocysteine (Hcy) has been linked to impaired endothelial function. We investigated whether treatment with pravastatin affects the Hcy levels. Moreover, we studied whether the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism affects coronary vasomotion at baseline and during the treatment with pravastatin. Fifty-one healthy, mildly hypercholesterolemic men (mean age 35+/-4 years) attended this randomised, double-blind, placebo-controlled study. The volunteers were randomised into groups with 6-month treatment with pravastatin (40 mg/day, n=25) or placebo (n=26). Coronary blood flow measurements with positron emission tomography at rest and during adenosine infusion as well as biochemical analyses were done at baseline and at the end of the treatment period. The Hcy concentration decreased significantly during the pravastatin therapy (-0.81+/-1.46 micromol/l, p=0.01), but not during placebo (0.02+/-2.39 micromol/l, p=0.97). The MTHFR polymorphism did not affect the Hcy concentration or coronary flow indices. Neither did the MTHFR polymorphism modulate the effects of pravastatin on coronary vasomotion. In conclusion, a 6-month therapy with pravastatin decreases Hcy concentration in Finnish healthy young men. The MTHFR genotype is neither a determinant of baseline coronary flow indices nor does it modulate the effect of pravastatin on coronary reactivity.
Tuomo Nieminen; Juhani Knuuti; Päivi Hämelahti; Mika Kähönen; Reijo Laaksonen; Tuula Janatuinen; Risto Vesalainen; Pirjo Nuutila; Hannu Jokela; Terho Lehtimäki
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-05-13
Journal Detail:
Title:  Vascular pharmacology     Volume:  47     ISSN:  1537-1891     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:    2007 Aug-Sep
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Department of Pharmacological Sciences, Medical School, FI-33014 University of Tampere, Finland.
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MeSH Terms
Anticholesteremic Agents / pharmacology*,  therapeutic use
Coronary Circulation / drug effects*,  genetics
Double-Blind Method
Homocysteine / blood,  drug effects*,  genetics
Hypercholesterolemia / drug therapy*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymorphism, Genetic
Positron-Emission Tomography
Pravastatin / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Anticholesteremic Agents; 454-28-4/Homocysteine; 58-61-7/Adenosine; 81093-37-0/Pravastatin; EC Reductase (NADPH2)

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