Document Detail

Coronary prevention and regression studies updated.
MedLine Citation:
PMID:  3052737     Owner:  NLM     Status:  MEDLINE    
There have been a multitude of clinical, animal and epidemiology studies which prove that high serum cholesterol and low density lipoprotein (LDL) cholesterol concentrations are specific causes of coronary artery disease (CAD). Although the variations in experimental design make comparisons difficult, the aggregate results of many human prevention trials since 1960 lead to the definite conclusion that a 10% lowering of serum cholesterol reduces the risk of CAD by one-sixth. Recently, other factors for CAD risk have been identified that will be useful in guiding treatment, namely serum high density lipoprotein (HDL) cholesterol, apolipoproteins B and AI, HDL triglycerides and phosphatidylcholine to free cholesterol ratio. Studies have shown that aggressive drug and diet therapy slows progression and causes regression of atheromas. Primary prevention of CAD is obviously preferable to secondary prevention. Also, the evidence to date indicates that prevention of CAD through lifestyle changes should begin in childhood.
J A Little
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Publication Detail:
Type:  Clinical Trial; Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  4 Suppl A     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-12-20     Completed Date:  1988-12-20     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  11A-15A     Citation Subset:  IM    
Department of Medicine, St Michael's Hospital, Toronto, Ontario.
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MeSH Terms
Cholesterol / blood*
Clinical Trials as Topic
Coronary Artery Disease / prevention & control
Coronary Disease / prevention & control*
North America
Risk Factors
Reg. No./Substance:

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