| Coronary pressure measurement to assess the hemodynamic significance of serial stenoses within one coronary artery: validation in humans. | |
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MedLine Citation:
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PMID: 11067791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: When several stenoses are present within 1 coronary artery, the hemodynamic significance of each stenosis is influenced by the presence of the other(s), and the calculation of coronary and fractional flow reserve (CFR and FFR) for each individual stenosis is confounded. Recently, we developed and experimentally validated a method to determine the true FFR of each stenosis as it would be after the removal of the other stenosis; the true FFR can be reliably predicted by coronary pressures measured before treatment at specific locations within the coronary artery using equations accounting for stenosis interaction. The aim of the present study was to test the validity of these equations in humans. METHODS AND RESULTS: In this study of 32 patients with 2 serial stenoses in 1 coronary artery, relevant pressures were measured before the intervention, after the treatment of 1 stenosis, and after the treatment of both stenoses. The true FFR of each stenosis (FFR(true)) was directly measured after the elimination of the other stenosis and compared with the value predicted (FFR(pred)) from the initial pressure measurements before treatment. Although the hyperemic gradient across 1 stenosis increased significantly (from 10+/-7 to 19+/-11 mm Hg after treatment of the other stenosis), FFR(pred) was close to FFR(true) in all patients (0.78+/-0.12 versus 0.78+/-0.11 mm Hg; r=0.92; Delta%=4+/-0%). Without accounting for stenosis interaction, the value of FFR for each stenosis would have been significantly overestimated (0.85+/-0.08; P:<0.01). CONCLUSIONS: Coronary pressure measurements made by a pressure wire at maximum hyperemia provide a simple, practical method for assessing the individual hemodynamic significance of multiple stenoses within the same artery. |
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Authors:
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N H Pijls; B De Bruyne; G J Bech; F Liistro; G R Heyndrickx; H J Bonnier; J J Koolen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 102 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-13 Completed Date: 2000-11-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2371-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Catharina Hospital, Eindhoven University of Technology, Eindhoven, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Blood Pressure Determination / instrumentation, statistics & numerical data* Coronary Angiography Coronary Circulation / physiology* Coronary Disease / diagnosis*, physiopathology, therapy Coronary Vessels / physiopathology* Female Heart Catheterization Hemodynamics / physiology* Humans Male Middle Aged Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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