Document Detail

Coronary pressure measurement after stenting predicts adverse events at follow-up: a multicenter registry.
MedLine Citation:
PMID:  12081986     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coronary stenting is associated with a restenosis rate of 15% to 20% at 6-month follow-up, despite optimum angiographic stent implantation. In this multicenter registry, we investigated the relation between optimum physiological stent implantation as assessed by poststent fractional flow reserve (FFR) and outcome at 6 months. METHODS AND RESULTS: In 750 patients, coronary pressure measurement at maximum hyperemia was performed after angiographically apparently satisfactory stent implantation. Poststenting FFR was calculated and related to major adverse events (including need for repeat target vessel revascularization) at 6 months. In 76 patients (10.2%), at least 1 adverse event occurred. Five patients died, 19 experienced myocardial infarction, and 52 underwent at least 1 repeat target vessel revascularization. By multivariate analysis, FFR immediately after stenting was the most significant independent variable related to all types of events. In 36% of the patients, FFR normalized (>0.95), and event rate was 4.9% in that group. In 32% of the patients, poststent FFR was between 0.90 and 0.95, and event rate was 6.2%. In 32% of patients, poststent FFR was <0.90, and event rate was 20.3%. In 6% of the patients, FFR was <0.80, and event rate was 29.5% (P<0.001). CONCLUSIONS: FFR after stenting is a strong independent predictor of outcome at 6 months.
Nico H J Pijls; Volker Klauss; Uwe Siebert; Eric Powers; Kenji Takazawa; William F Fearon; Javier Escaned; Yukio Tsurumi; Takashi Akasaka; Habib Samady; Bernard De Bruyne;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  105     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-25     Completed Date:  2002-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2950-4     Citation Subset:  AIM; IM    
Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands.
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MeSH Terms
Blood Pressure
Coronary Circulation*
Coronary Restenosis / etiology,  physiopathology*
Follow-Up Studies
Middle Aged
Stents / adverse effects*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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