| Coronary plaque response after drug eluting stent implantation assessed by serial optical coherence tomography analysis. | |
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MedLine Citation:
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PMID: 22340236 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: In general, percutaneous coronary intervention (PCI) relieves vessel stenosis by implantation of a stent, however, the relationship between plaque characteristics and response after stenting is not clear. METHODS: We enrolled 68 patients (68 vessels) with diagnosed unstable angina pectoris that prospectively underwent PCI and an optical coherence tomography (OCT) examination was done before and after stenting. Coronary plaques were classified as fibrous, lipid-rich and calcified plaque according to OCT examination, and fibrous cap thickness, lumen eccentricity, stent expansion, stent malapposition, tissue prolapse, thrombosis, dissection and stent symmetry were noted. RESULTS: The frequency of prolapse was higher in lipid-rich plaques than fibrous plaques (85% vs. 40%, P < 0.001). Dissection most often occurred in fibrous plaque compared with lipid-rich and calcified plaques (60% vs. 32% vs. 29%, P < 0.001). The frequency of stent strut malapposition in calcified plaques was higher than firous and lipid-rich plaques (71% vs. 40% vs. 5%, P < 0.001). In-stent micro-thrombosis was detected only in lipid-rich plaques, with a frequency of 37% (15/41). The risk factors of micro-thrombosis after PCI were cap thickness (OR 0.903, 95%CI 0.829 - 0.985), lumen eccentricity (OR 1.147, 95%CI 1.012 - 1.30), and stent length (OR 1.495, 95%CI 1.032 - 2.166). CONCLUSION: Plaque response after PCI is associated with its characteristics, and of those, micro-thrombosis after stenting in lipid-rich plaques was the most significant finding and can be predicted. |
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Authors:
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Feng Tian; Yun-Dai Chen; Lian Chen; Zhi-Jun Sun; Chang-Fu Liu; Jun Guo; Qin-Hua Jin; Jin-da Wang; Lu-Yue Gai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 124 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-02-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 3752-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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