| Coronary perfusion catheter: its effectiveness in an experimental model of acute coronary occlusion. | |
| | |
MedLine Citation:
|
PMID: 2239655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effectiveness of a coronary perfusion catheter was studied in an animal model of acute coronary occlusion. Systemic hemodynamic variables, regional myocardial blood flow (RMBF) in the subepicardium and subendocardium, and regional systolic function (systolic segmental shortening) of the area perfused by the circumflex coronary artery (CX) were measured in eight anesthetized dogs. After baseline measurements, the CX coronary artery was occluded with a silk snare and measurements were repeated after 5 minutes of ischemia (occlusion No. 1). The snare was released and 1 hour later the snare occlusion was repeated after placement of a perfusion catheter in the CX coronary artery. After 5 minutes, measurements were repeated (occlusion No. 2). To determine the long-term effectiveness of the catheter, hemodynamic variables and regional function measurements were then obtained every 15 minutes for a total of 60 minutes. During occlusion No. 1, RMBF decreased from 1.30 +/- 0.20 to 0.41 +/- 0.13 ml.min-1.gm-1 (p less than 0.01), and subendocardial RMBF decreased from 1.44 +/- .24 to 0.34 +/- 0.15 ml.min-1.gm-1 (p less than 0.01). After insertion of the perfusion catheter (occlusion No. 2), subepicardial RMBF was maintained at 0.97 +/- 0.16 and subendocardial RMBF was maintained at 0.78 +/- 0.13 ml.min-1.gm-1; during occlusion No. 2 subepicardial RMBF was greater (p less than 0.05) than occlusion No. 1 and was not different from baseline.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
A E Moreyra; A Macris; J B Kostis; P Scholz |
Related Documents
:
|
7432065 - Pathology of vascular sensorineural hearing impairment. 1601025 - Vascular mechanisms to induce acute pancreatitis. 7754845 - Simulation study on bypass and therapeutic occlusion in the posterior circulation. 20957645 - Mouse models of global cerebral ischemia. 21227615 - The use of routine imaging data in diagnosis of cerebral pseudoaneurysm prior to angiog... 8943455 - Embolic thrombus on mitral anulus calcification. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American heart journal Volume: 120 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1990 Nov |
Date Detail:
|
Created Date: 1990-12-04 Completed Date: 1990-12-04 Revised Date: 2006-02-27 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1031-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903-0019. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arterial Occlusive Diseases / therapy* Catheters, Indwelling* Coronary Circulation Coronary Disease / therapy* Dogs Heart Catheterization / instrumentation* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Persistent uptake of indium-111-antimyosin monoclonal antibody in patients with myocardial infarctio...
Next Document: Dose-dependent reduction of myocardial infarct size with the perfluorochemical Fluosol-DA.