Document Detail

Coronary patency after thrombolysis.
MedLine Citation:
PMID:  8328197     Owner:  NLM     Status:  MEDLINE    
The immediate direct aim of thrombolytic therapy is rapid recanalization of the infarct-related coronary artery. Coronary patency rates observed in the different placebo-controlled and direct comparative trials of thrombolytic agents at different times after the onset of treatment are summarized. It is concluded that 1) for early reperfusion rt-PA is more effective than the other agents, 2) but that at the time of hospital discharge the observed patency rates are very similar for the different fibrinolytic agents and, surprisingly, not different from those obtained with antithrombotic treatment alone (= combined effect of endogenous thrombolysis and antithrombotic treatment!). New approaches to improve early reperfusion rates are discussed.
F Van de Werf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Zeitschrift für Kardiologie     Volume:  82 Suppl 2     ISSN:  0300-5860     ISO Abbreviation:  Z Kardiol     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-09     Completed Date:  1993-08-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0360430     Medline TA:  Z Kardiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
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MeSH Terms
Coronary Circulation / drug effects*
Dose-Response Relationship, Drug
Fibrinolytic Agents / therapeutic use*
Myocardial Infarction / drug therapy*
Thrombolytic Therapy*
Vascular Patency / drug effects*
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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