| Coronary microvascular resistance in hypertensive cats. | |
| | |
MedLine Citation:
|
PMID: 1742865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chronic systemic hypertension has been shown to alter the distribution of vascular resistance in many microvascular beds. The purposes of this study were to assess the effects of chronic systemic hypertension on the pressure distribution in the coronary microcirculation and to determine the microvascular site where coronary vascular resistance is increased. Cats were made hypertensive using a one-kidney, one-wrap model (Page model). A servonulling system was used to directly measure pressures in the epimyocardial microvessels of the beating left ventricle in normotensive and hypertensive cats. In chronically hypertensive cats, mean arterial pressure was 153 +/- 5 mm Hg compared with 98 +/- 3 mm Hg in normotensive cats (p less than 0.05). Left ventricular mass was increased approximately 34% in hypertensive cats (9.4 +/- 0.3 versus 7.0 +/- 0.3 g, p less than 0.05). Myocardial perfusion measured using radiolabeled microspheres was not different between hypertensive and normal cats. Coronary vascular resistance of the left ventricle was increased in hypertensive cats (0.90 +/- 0.08 versus 0.66 +/- 0.05 mm Hg x min x 100 g/ml, p less than 0.05). Microvascular pressures were measured in three groups of microvessels: small, less than 200 microns; medium, 200-300 microns; and large, greater than or equal to 300 microns. Mean microvascular pressures of large, medium, and small arterial microvessels in hypertensive cats were 144 +/- 8, 127 +/- 6, and 115 +/- 7 mm Hg, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
H Kanatsuka; K G Lamping; C L Eastham; M L Marcus; K C Dellsperger |
Related Documents
:
|
8611285 - Safety and efficacy of computerized closed-loop delivery of arbutamine: a new pharmacol... 2097065 - Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arter... 4006105 - Removal of the endothelium potentiates canine large coronary artery constrictor respons... 2957905 - Recovery of systolic and diastolic left ventricular function after a 60-second coronary... 10875085 - Glaucoma and ocular hypertension in pediatric patients with cataracts. 3383365 - Passive properties of canine left ventricle: diastolic stiffness and restoring forces. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation research Volume: 68 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1991 Mar |
Date Detail:
|
Created Date: 1992-01-13 Completed Date: 1992-01-13 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 726-33 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City 52242. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arteries Blood Pressure Cats Coronary Circulation* Gases / blood Hemodynamics Hypertension / blood, physiopathology* Microcirculation Veins |
| Grant Support | |
ID/Acronym/Agency:
|
HL-20827/HL/NHLBI NIH HHS; HL-32295/HL/NHLBI NIH HHS; HL-39050/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Gases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fatty acid metabolism and contractile function in the reperfused myocardium. Multinuclear NMR studie...
Next Document: Comparison of crossbridge dynamics between intact and skinned myocardium from ferret right ventricle...