Document Detail

Coronary magnetic resonance angiography for the detection of coronary stenoses.
MedLine Citation:
PMID:  11756576     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An accurate, noninvasive technique for the diagnosis of coronary disease would be an important advance. We investigated the accuracy of coronary magnetic resonance angiography among patients with suspected coronary disease in a prospective, multicenter study. METHODS: Coronary magnetic resonance angiography was performed during free breathing in 109 patients before elective x-ray coronary angiography, and the results of the two diagnostic procedures were compared. RESULTS: A total of 636 of 759 proximal and middle segments of coronary arteries (84 percent) were interpretable on magnetic resonance angiography. In these segments, 78 (83 percent) of 94 clinically significant lesions (those with a > or = 50 percent reduction in diameter on x-ray angiography) were also detected by magnetic resonance angiography. Overall, coronary magnetic resonance angiography had an accuracy of 72 percent (95 percent confidence interval, 63 to 81 percent) in diagnosing coronary artery disease. The sensitivity, specificity, and accuracy for patients with disease of the left main coronary artery or three-vessel disease were 100 percent (95 percent confidence interval, 97 to 100 percent), 85 percent (95 percent confidence interval, 78 to 92 percent), and 87 percent (95 percent confidence interval, 81 to 93 percent), respectively. The negative predictive values for any coronary artery disease and for left main artery or three-vessel disease were 81 percent (95 percent confidence interval, 73 to 89 percent) and 100 percent (95 percent confidence interval, 97 to 100 percent), respectively. CONCLUSIONS: Among patients referred for their first x-ray coronary angiogram, three-dimensional coronary magnetic resonance angiography allows for the accurate detection of coronary artery disease of the proximal and middle segments. This noninvasive approach reliably identifies (or rules out) left main coronary artery or three-vessel disease.
W Y Kim; P G Danias; M Stuber; S D Flamm; S Plein; E Nagel; S E Langerak; O M Weber; E M Pedersen; M Schmidt; R M Botnar; W J Manning
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  345     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1863-9     Citation Subset:  AIM; IM    
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Coronary Angiography
Coronary Stenosis / diagnosis*,  radiography
Imaging, Three-Dimensional
Magnetic Resonance Angiography* / methods
Middle Aged
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Comment In:
N Engl J Med. 2001 Dec 27;345(26):1909-10   [PMID:  11756583 ]
N Engl J Med. 2002 May 2;346(18):1413-4; author reply 1413-4   [PMID:  11986421 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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