Document Detail

Coronary intimal thickenings and lipids in Finnish children who died violently.
MedLine Citation:
PMID:  3867229     Owner:  NLM     Status:  MEDLINE    
Intimal thickenings of the coronary arteries were found in healthy children who died violently, of both sexes even in children under 5 years of age. The average incidence was 53 % of the 75 cases. Splitting of the internal elastic lamina was the primary finding, followed by local increase in smooth muscle cells. The thickening could occupy 50 % of the coronary lumen. The accumulation of esterified cholesterol in the coronary arteries began before the age of 10 years. The fatty acid composition of the cholesterol esters suggests that they are derived from the blood. The question whether the thickenings are precursors of forthcoming coronary atheromas needs further detailed studies, especially in young adults.
J Hirvonen; S Ylä-Herttuala; H Laaksonen; M Möttönen; T Nikkari; E Pesonen; J Raekallio; H K Akerblom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica. Supplement     Volume:  318     ISSN:  0300-8843     ISO Abbreviation:  Acta Paediatr Scand Suppl     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-11     Completed Date:  1986-03-11     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  0173166     Medline TA:  Acta Paediatr Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  221-4     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Cholesterol / blood
Cholesterol Esters / blood
Coronary Disease / blood,  pathology*
Coronary Vessels / pathology*
Elastic Tissue / pathology
Infant, Newborn
Lipids / blood*
Muscle, Smooth, Vascular / pathology
Phospholipids / blood
Prospective Studies
Reg. No./Substance:
0/Cholesterol Esters; 0/Lipids; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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