Document Detail


Coronary heart disease in male twins: seven-year follow-up of discordant pairs.
MedLine Citation:
PMID:  1036375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an investigation in 1967 of about 100 male twin pairs collected from the Swedish Twin Register, discordance with respect to the presence of CHD was found in 37 pairs of which 19 were MZ. The investigation included physical examination, cholesterol measurements, and an interview regarding, among other things, smoking habits. In a follow-up study in 1974 -- seven years after the original investigation -- all but one of the 37 twins regarded in 1967 as free from overt CHD could be traced. Ten of the 36 twins had developed symptoms of overt CHD (angina pectoris or infarction); 18 twins were still healthy, 2 had died from other causes, and 6 had questionable complaints of breast pains. In a comparison of the two groups of twins with and without symptoms of overt CHD, no differences were found with respect to blood pressure, serum cholesterol, or smoking habits, as presented at the 1967 investigation. It is concluded that none of these factors seemed to influence the future development of CHD in twins apparently tainted with a heredity for this disease.
Authors:
I Liljefors
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta geneticae medicae et gemellologiae     Volume:  25     ISSN:  0001-5660     ISO Abbreviation:  Acta Genet Med Gemellol (Roma)     Publication Date:  1976  
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370314     Medline TA:  Acta Genet Med Gemellol (Roma)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  276-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / genetics
Blood Pressure
Cholesterol / blood
Coronary Disease / genetics*
Diseases in Twins*
Exercise Test
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction / genetics
Pregnancy
Twins, Dizygotic
Twins, Monozygotic
Chemical
Reg. No./Substance:
57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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