| Coronary heart disease: a disorder of growth. | |
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MedLine Citation:
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PMID: 12566719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new 'developmental' model for the origins of coronary heart disease and the related disorders of type 2 diabetes, hypertension and stroke is emerging. The finding that people who develop these disorders have altered growth in utero, during infancy and childhood provides a new starting point for research. The immediate prospect for prevention is through protecting infant growth and preventing accelerated weight gain in children made vulnerable to later disease by small size at birth and during infancy. Ultimately we need to optimize maternal diet and composition before and during pregnancy. Despite current levels of nutrition in Western countries the nutrition of many fetuses and infants remains suboptimal because the nutrients available are unbalanced or because their delivery is constrained by the long and vulnerable fetal supply line. |
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Authors:
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D J P Barker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hormone research Volume: 59 Suppl 1 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-02-04 Completed Date: 2003-11-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 35-41 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK. djpb@mrc.soton.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Coronary Disease / etiology* Diabetes Mellitus, Type 2 / etiology Female Growth Disorders / complications* Humans Hypertension / etiology Income Male Nutritional Physiological Phenomena Pregnancy Proportional Hazards Models Risk Factors |
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