Document Detail

Coronary heart disease: a disorder of growth.
MedLine Citation:
PMID:  12566719     Owner:  NLM     Status:  MEDLINE    
A new 'developmental' model for the origins of coronary heart disease and the related disorders of type 2 diabetes, hypertension and stroke is emerging. The finding that people who develop these disorders have altered growth in utero, during infancy and childhood provides a new starting point for research. The immediate prospect for prevention is through protecting infant growth and preventing accelerated weight gain in children made vulnerable to later disease by small size at birth and during infancy. Ultimately we need to optimize maternal diet and composition before and during pregnancy. Despite current levels of nutrition in Western countries the nutrition of many fetuses and infants remains suboptimal because the nutrients available are unbalanced or because their delivery is constrained by the long and vulnerable fetal supply line.
D J P Barker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hormone research     Volume:  59 Suppl 1     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2003  
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-11-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
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MeSH Terms
Birth Weight
Coronary Disease / etiology*
Diabetes Mellitus, Type 2 / etiology
Growth Disorders / complications*
Hypertension / etiology
Nutritional Physiological Phenomena
Proportional Hazards Models
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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