Document Detail

Coronary heart disease after mediastinal irradiation for Hodgkin's disease.
MedLine Citation:
PMID:  1251845     Owner:  NLM     Status:  MEDLINE    
Attention is called to the development of coronary heart disease in two patients several years after they received mediastinal irradiation for Hodgkin's disease. One patient, a 33 year old man, died suddenly eight years after irradiation; necropsy disclosed marked narrowing of all three major coronary arteries. In addition to severe intima fibrous thickening, there also was considerable adventitial scarring of the coronary arteries. This type of coronary sclerosis is different from that seen in the usual patient with coronary heart disease. The second patient, a 42 year old man, had an acute myocardial infarction on two occasions, the first six years after mediastinal irradiation. Observations in previously described patients with coronary heart disease almost surely induced by therapeutic irradiation for Hodgkin's disease are reviewed.
R A McReynolds; G L Gold; W C Roberts
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  60     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-04-23     Completed Date:  1976-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Disease / etiology*,  pathology
Coronary Vessels / radiation effects
Hodgkin Disease / radiotherapy*
Mediastinal Neoplasms / radiotherapy*
Radiation Injuries / etiology*
Radiotherapy / adverse effects*
Radiotherapy Dosage
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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