Document Detail


Coronary haemodynamic effects of short-term intravenous administration of gallopamil in patients with stable exertional angina.
MedLine Citation:
PMID:  3566979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of short term intravenous administration of gallopamil on coronary haemodynamic variables were studied in 10 patients with stable exertional angina and angiographically confirmed coronary artery disease that affected the proximal portion of the left anterior descending artery. Blood flow in the great cardiac vein was measured by a thermodilution technique, both at rest and during ischaemia induced by atrial pacing, before and after intravenous administration of gallopamil (0.02 mg/kg as a bolus dose given over three minutes, followed by an infusion of 0.0005 mg/kg/min). Gallopamil significantly prolonged the mean (SD) duration of pacing that was tolerated (11 (2.6) vs 14.8 (2.4] min, significantly increased the mean (SD) peak heart rate attained during pacing (142 (15) vs 158 (11) beats/min), and reduced mean (SD) arterial pressure (133 (17) vs 116 (17) mm Hg). There were no changes in mean (SD) blood flow in the great cardiac vein (134.1 (57) vs 112.9 (38) ml/min, mean (SD) anterior regional coronary resistance (1.18 (0.6) vs 1.15 (0.5) mm Hg/ml/min), and mean (SD) anterior regional myocardial oxygen consumption (16.6 (6) vs 13.7 (4) ml/min). These data confirm that gallopamil is an effective antianginal agent and suggest that a reduction of myocardial oxygen demand is the predominant mechanism by which the drug exerts its beneficial effects.
Authors:
S De Servi; M Ferrario; S Ghio; A Mussini; L Angoli; E Bramucci; A Bartoli; E Poma; R Rondanelli; G Specchia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  57     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-01     Completed Date:  1987-06-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  226-31     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / drug therapy*,  metabolism,  physiopathology
Coronary Circulation / drug effects*
Female
Gallopamil / therapeutic use*
Hemodynamics / drug effects
Humans
Male
Middle Aged
Oxygen Consumption / drug effects
Physical Exertion*
Chemical
Reg. No./Substance:
16662-47-8/Gallopamil
Comments/Corrections

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