Document Detail

Coronary flow velocity reserve after percutaneous interventions is predictive of periprocedural outcome.
MedLine Citation:
PMID:  11927525     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Because heterogeneous results have been reported, we assessed coronary flow velocity changes in individuals who underwent percutaneous transluminal coronary angioplasty (PTCA) and examined their impact on clinical outcome. METHODS AND RESULTS: As part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) II study, 379 patients underwent Doppler flow-guided angioplasty. All patients were evaluated according to their coronary flow velocity reserve (CFVR) results (> or =2.5 or < 2.5) at the end of the procedure. A CFVR < 2.5 after angioplasty was associated with an elevated baseline blood flow velocity in both the target artery and reference artery. CFVR before PTCA and CFVR in the reference artery were independent predictors of an optimal CFVR after balloon angioplasty (CFVR before PTCA: odds ratio [OR], 2.26; 95% confidence interval [CI], 1.57 to 3.24; CFVR in reference artery: OR, 1.90; 95% CI, 1.21 to 2.98; both P<0.001) and stent implantation (before PTCA: OR, 2.54; 95% CI, 1.47 to 4.36; reference artery: OR, 1.97; 95% CI, 1.07 to 3.87; both P<0.05). A low CFVR at the end of the procedure was an independent predictor of major adverse cardiac events (MACE) at 30 days (OR, 4.71; 95% CI, 1.14 to 25.92; P=0.034) and at 1 year (OR, 2.06; 95% CI, 1.16 to 3.66; P=0.014). After excluding MACE at 30 days, no difference in MACE at 1 year was observed between the patients with and without a CFVR < 2.5 at the end of the procedure. CONCLUSIONS: A low postprocedural CFVR was associated with a worse periprocedural outcome (which was related to microcirculatory disturbances), but there was no significant difference at late follow-up.
M Albertal; M Voskuil; J J Piek; B de Bruyne; G Van Langenhove; P I Kay; M A Costa; E Boersma; T Beijsterveldt; J E Sousa; J A Belardi; P W Serruys;
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation     Volume:  105     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-02     Completed Date:  2002-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1573-8     Citation Subset:  AIM; IM    
Thoraxcenter, Rotterdam, the Netherlands.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Blood Flow Velocity
Coronary Angiography
Coronary Circulation*
Disease-Free Survival
Echocardiography, Doppler / methods*
Follow-Up Studies
Middle Aged
Multivariate Analysis
Myocardium / enzymology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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