| Coronary flow and resistance reserve in patients with chronic aortic regurgitation, angina pectoris and normal coronary arteries. | |
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MedLine Citation:
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PMID: 3278034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular hypertrophy has been found to be associated with a reduction of coronary vascular reserve, which could be responsible for episodes of myocardial ischemia. To evaluate coronary flow and resistance reserve in patients with chronic aortic regurgitation, coronary sinus blood flow and coronary resistance were measured before and after an intravenous dipyridamole infusion (0.14 mg/kg per min X 4 min) in eight control subjects and eight patients with aortic regurgitation, exertional angina pectoris and normal coronary arteriograms. Coronary flow reserve, evaluated by the dipyridamole/basal coronary sinus blood flow ratio, and coronary resistance reserve, evaluated by the basal/dipyridamole coronary resistance ratio, were both significantly reduced in patients with aortic regurgitation (1.67 +/- 0.40 versus 4.03 +/- 0.52 in control subjects, p less than 0.001 and 1.71 +/- 0.50 versus 4.38 +/- 0.88 in control subjects, p less than 0.001, respectively). In patients with aortic regurgitation, basal coronary sinus blood flow was higher than in control subjects (276 +/- 81 versus 105 +/- 24 ml/min, respectively, p less than 0.001) and basal coronary resistance was lower (0.31 +/- 0.13 versus 0.95 +/- 0.17 mm Hg/ml per min, respectively, p less than 0.001), but coronary blood flow and resistance after dipyridamole were not significantly different in the two groups (461 +/- 159 versus 418 +/- 98 ml/min in control subjects, 0.19 +/- 0.11 versus 0.22 +/- 0.04 mm Hg/ml per min in control subjects, respectively). These data demonstrate that coronary reserve is severely reduced in patients with chronic aortic regurgitation and exertional angina.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Nitenberg; J M Foult; I Antony; F Blanchet; M Rahali |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 11 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-03-28 Completed Date: 1988-03-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 478-86 Citation Subset: AIM; IM |
Affiliation:
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Laboratoire d'Hémodynamique et d'Angiocardiographie, INSERM U.251, CHU Xavier Bichat, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angina Pectoris / drug therapy, physiopathology* Aortic Valve Insufficiency / drug therapy, physiopathology* Chronic Disease Coronary Circulation* / drug effects Coronary Vessels / drug effects Dipyridamole / pharmacology, therapeutic use Female Heart Catheterization Hemodynamics / drug effects Humans Male Middle Aged Vascular Resistance* / drug effects |
| Chemical | |
Reg. No./Substance:
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58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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