| Coronary flow reserve is impaired in subclinical hypothyroidism. | |
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MedLine Citation:
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PMID: 18000961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Although the cardiovascular system is highly sensitive to thyroid hormones, the cardiovascular effects of subtle thyroid dysfunction such as subclinical hypothyroidism (SHT) remain unclear. Therefore, we investigated coronary flow reserve (CFR) reflecting coronary microvascular function in patients with SHT. METHODS: Fifty subjects with SHT and 30 control subjects with normal serum thyroid hormones and TSH levels were included in this study. Coronary diastolic peak flow velocities were measured at baseline and after dipyridamole infusion. CFR was calculated as the ratio of hyperemic to baseline diastolic peak velocity. RESULTS: Age, gender, diastolic and systolic blood pressure, body mass index (BMI), serum lipid parameters, and thyroid hormone levels were similar between the groups. Heart rate was significantly lower in the SHT group. Left ventricular diastolic filling parameters were significantly different in the SHT group while other echocardiographic parameters were similar. CFR values were significantly lower in subjects with SHT than in the control group (2.38 +/- 0.44 vs. 2.98 +/- 0.47, p < 0.0001). CONCLUSIONS: These findings suggest that CFR, which reflects coronary microvascular function, is impaired in patients with SHT. |
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Authors:
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Semra Baycan; Dogan Erdogan; Mustafa Caliskan; Baris Onder Pamuk; Ozgur Ciftci; Hakan Gullu; Aylin Yildirir; Nilgun D Guvener; Haldun Muderrisoglu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 30 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-21 Completed Date: 2008-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 562-6 Citation Subset: IM |
Affiliation:
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Cardiology Department, Baskent University, Faculty of Medicine, Ankara, Turkey. semrab@baskent-kon.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Flow Velocity Body Mass Index Case-Control Studies Coronary Circulation* Diastole Echocardiography / methods Female Humans Hypothyroidism / complications*, therapy Male Middle Aged Myocardial Contraction Myocardium / pathology Thyrotropin / metabolism |
| Chemical | |
Reg. No./Substance:
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9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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