Document Detail


Coronary flow reserve and exercise capacity in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  8897065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate the relation of coronary flow velocity (CFV) and coronary flow reserve (CFR) to exercise capacity in ten verapamil-treated patients with hypertrophic cardiomyopathy (HC). Using Doppler transesophageal echocardiography, we assessed diastolic CFV in the proximal left anterior descending coronary artery at baseline and after administering 0.56 mg/kg intravenous dipyridamole. The CFR was calculated as the post-dipyridamole/baseline diastolic CFV ratio. A maximal symptom-limited exercise treadmill test was performed according to a modified Bruce protocol and the exercise capacity was expressed as metabolic equivalents. The mean value for baseline diastolic CFV was 59 +/- 27 cm/s; this increased after dipyridamole to 134 +/- 57 cm/s. The CFR was 2.37 +/- 0.67. Baseline diastolic CFV correlated negatively with both exercise duration (r = -0.69; P < 0.05) and value for metabolic equivalents (r = -0.70; P < 0.05). CFR was weakly and non-significantly related to exercise duration (r = 0.40; P > 0.05) and to the value for metabolic equivalents (r = 0.32; P > 0.05). Shortening of exercise time and decreasing metabolic equivalents were correlated with increased baseline diastolic CFV. Dipyridamole-assessed CFR, was weakly related to parameters of exercise capacity.
Authors:
P P Dimitrow; M Krzanowski; W Bodzoń; A Szczeklik; J S Dubiel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  11     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-13     Completed Date:  1997-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  160-4     Citation Subset:  IM    
Affiliation:
Second Department of Cardiology, Collegium Medicum Jagiellonian University, Kraków, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity
Cardiomyopathy, Hypertrophic / drug therapy,  physiopathology,  ultrasonography*
Coronary Circulation* / drug effects
Dipyridamole / administration & dosage,  diagnostic use*
Echocardiography, Transesophageal*
Exercise Tolerance* / drug effects
Humans
Injections, Intravenous
Sensitivity and Specificity
Vasodilator Agents / administration & dosage,  diagnostic use*
Verapamil / therapeutic use
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 52-53-9/Verapamil; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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