Document Detail

Coronary flow reserve correlates left ventricular diastolic dysfunction in patients with dilated cardiomyopathy.
MedLine Citation:
PMID:  12508195     Owner:  NLM     Status:  MEDLINE    
The relationship between altered coronary circulation and left ventricular (LV) function in dilated cardiomyopathy (DCM) remains unclear. We used the Doppler guidewire and transthoracic echo Doppler in 24 DCM patients to investigate the relationship between coronary flow reserve (CFR) and LV systolic/diastolic function, trying to predict diastolic dysfunction and evaluate DCM severity with CFR. CFR correlated better with the deceleration time (DT) of the E-wave and the ratio of E-wave peak value to that of the A-wave (E/A) than with LV ejection fraction (EF). The optimal CFR cutoff value for predicting the restrictive pattern of transmitral flow velocity (DT = 120 msec) was 2.6 (sensitivity 91%, specificity 100%). Dividing patients into two groups around the CFR = 2.6 cutoff, differences in DT and E/A between groups were more prominent than those for EF. CFR correlates better with LV diastolic than systolic function and may be useful for predicting diastolic dysfunction in DCM patients.
Masakazu Teragaki; Shiro Yanagi; Iku Toda; Kazuo Sakamoto; Kazuyoshi Hirota; Kazuhide Takeuchi; Junichi Yoshikawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  58     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-31     Completed Date:  2003-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Department of Cardiology and Internal Medicine, Osaka City University, Osaka, Japan.
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MeSH Terms
Blood Flow Velocity / physiology
Cardiac Volume / physiology*
Cardiomyopathy, Dilated / physiopathology*,  radiography,  ultrasonography*
Coronary Angiography
Coronary Circulation / physiology
Diastole / physiology*
Echocardiography, Doppler*
Hemodynamics / physiology
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Severity of Illness Index
Stroke Volume / physiology
Ventricular Dysfunction, Left / physiopathology*,  radiography,  ultrasonography*

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