Document Detail

Coronary flow reserve and coronary microvascular functions are strongly related to serum uric acid concentrations in healthy adults.
MedLine Citation:
PMID:  16374135     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Uric acid is a well known antioxidant; however, the relationship between serum uric acid levels and oxidative stress-caused disorders including cardiovascular diseases is not clear yet. Transthoracic Doppler echocardiographic measurement of coronary flow reserve is a useful tool to investigate coronary flow reserve and coronary microvascular functions. In this study, we investigated the possible association between serum uric acid concentrations and coronary flow reserve in healthy adults. METHODS: One hundred healthy volunteers with normal uric acid levels, between 18 and 55 years of age, were included in this study. The study group was divided into two with regard to the serum uric acid levels. Coronary diastolic peak flow velocities were measured at baseline and after dipyridamole infusion (0.56 mg/kg over 4 min) using echocardiography. RESULTS: Coronary flow reserve and hyperemic mean peak flow velocity were significantly greater in participants with lower serum uric acid concentrations (< or =234 micromol/l for women, < or =302 micromol/l for men) than in those with higher serum uric acid concentrations (>234 micromol/l for women, >302 micromol/l for men) (2.91+/-0.5 vs. 2.47+/-0.5, P<0.001; 66.8+/-11.4 vs. 61.1+/-16.5, P=0.04). The baseline mean peak flow velocity was significantly greater in participants with higher serum uric acid concentrations than in those with lower serum uric acid concentrations (24.7+/-4.1 vs. 23.1+/-2.4, P=0.02). CONCLUSION: Lower serum uric acid concentrations might be regarded as indicative of coronary microvascular and conductance vessel functionality.
Dogan Erdogan; Hakan Gullu; Mustafa Caliskan; Ibrahim Yildirim; Taner Ulus; Muhammet Bilgi; Sema Yilmaz; Haldun Muderrisoglu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  17     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-14     Citation Subset:  IM    
Department of Cardiology, Konya Teaching and Medical Research Center, Baskent University, Konya, Turkey.
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MeSH Terms
Biological Markers / blood
Blood Flow Velocity / physiology*
Coronary Circulation / physiology*
Coronary Vessels / physiology*,  ultrasonography
Echocardiography, Doppler
Microcirculation / physiology
Middle Aged
Myocardial Contraction / physiology
Oxidative Stress / physiology
Reference Values
Uric Acid / blood*
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

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